Hepato-neuro lab

Christopher F. Rose, Ph.D.

Christopher F. Rose

 Dr Rose is a full Professor at the Department of Medicine at the Université de Montréal and researcher at CRCHUM since 2006. He's also affiliated to pharmacology, neuroscience and nutrition departments.

 Full Professor, Departments of medicine, pharmacology, neurosciences and nutrition, Université de Montréal

 2006 - now

  Social media profiles :

Career


Related Publications

OpenAccess
Lessons on brain edema in HE: from cellular to animal models and clinical studies.

Lessons on brain edema in HE: from cellular to animal models and clinical studies.

Katarzyna Pierzchala, Anna Hadjihambi, Jessie Mosso, Rajiv Jalan, Christopher F. Rose, Cristina Cudalbu.

OpenAccess
175 Years of Bilirubin Testing: Ready for Point-of-Care?

175 Years of Bilirubin Testing: Ready for Point-of-Care?

Natalie Guirguis, Antoine-Xavier Bertrand, Christopher F. Rose, Simon Matoori.

Measuring and Interpreting Ammonia Levels in Cirrhosis

Measuring and Interpreting Ammonia Levels in Cirrhosis

Maria Pilar Ballester, Christopher F. Rose, Juan-Antonio Carbonell-Asins, Rajiv Jalan.

Constant alcohol consumption exacerbates hepatic encephalopathy and induces neuronal cell loss in rats with chronic liver disease.

Constant alcohol consumption exacerbates hepatic encephalopathy and induces neuronal cell loss in rats with chronic liver disease.

Farzaneh Tamnanloo, Xiaoru Chen, Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Neurological dysfunction is improved after faecal microbiota transplantation in rats with bile duct ligated-induced chronic liver disease.

Neurological dysfunction is improved after faecal microbiota transplantation in rats with bile duct ligated-induced chronic liver disease.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, André Marette, Chantal Bémeur, Christopher F. Rose.

Exacerbation du déclin neurologique et perte cellulaire neuronale causée par la consommation continuelle d’alcool chez les rats ayant une maladie de foie chronique.

Farzaneh Tamnanloo, Xiaoru Chen, Mélanie Tremblay, Christopher F. Rose.

La transplantation de microbiote fécal améliore les troubles neurologiques chez les rats avec une maladie hépatique chronique induite par la ligature du canal biliaire.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Kraine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

L’acide urique comme facteur de risque pour les complications cognitives de la cirrhose du foie : développement et validation d’un nouveau modèle murin.

Sydnée L’Écuyer, Alexandra Matesan, Farzaneh Tamnanloo, Mariana Oliveira, Mélanie Tremblay, Emmanuel Charbonney, Christopher F. Rose.

OpenAccess
Nutritional education strategies for patients with cirrhosis: A narrative review.

Nutritional education strategies for patients with cirrhosis: A narrative review.

Manila Sophasath, Alexandre Brisset, Christopher F. Rose, Chantal Bémeur.

Oral

L’acide urique comme facteur de risque pour les complications cognitives de la cirrhose du foie : développement et validation d’un nouveau modèle murin.

Sydnée L’Écuyer, Alexandra Matesan, Farzaneh Tamnanloo, Mariana Oliveira, Mélanie Tremblay, Emmanuel Charbonney, Christopher F. Rose.

Oral

Le rôle de la consommation constante d'alcool sur le déclin neurologique et la perte de cellules neuronales chez les rats atteints d'une maladie hépatique chronique.

Farzaneh Tamnanloo, Xiaoru Chen, Mélanie Tremblay, Christopher F. Rose.

Oral

Hyperuricemia as an implicated factor in cognitive impairments in chronic liver disease: developing a new murine model.

Sydnée L’Écuyer, Alexandra Matesan, Farzaneh Tamnanloo, Mariana Oliveira, Mélanie Tremblay, Emmanuel Charbonney, Christopher F. Rose.

Constant alcohol consumption exacerbates neurological decline and causes neuronal cell loss in rats with chronic liver disease.

Farzaneh Tamnanloo, Xiaoru Chen, Mélanie Tremblay, Christopher F. Rose.

Neurological impairment in rats with bile duct ligated-induced chronic liver disease are improved after faecal microbiota transplantation.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Dépistage à long terme de la malnutrition, de la sarcopénie et de la fragilité physique chez les receveurs d’une transplantation hépatique : étude transversale.

Amal Trigui, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Oral

Le guide la nutrition pour la cirrhose : est-ce une ressource éducative adaptée aux patients atteints de maladie hépatique chronique?

Manila Sophasath, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Prevalence of overweight and obesity in patients on the liver transplant waiting list: Experience of a referral center, Centre hospitalier de l’Université de Montréal (CHUM).

Isaac Ruiz, Mélanie Tremblay, Crystèle Hogue, Amal Trigui, Geneviève Huard, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Semi-targeted LC-HRMS/MS analysis of bile acids to decipher the effects of drug-induced liver injury in humans

Myriam Mireault, Constantine J. Karvellas, Christopher F. Rose, Lekha Sleno.

Constant alcohol consumption exacerbates neurological decline and causesneuronal cell loss in rats with chronic liver disease

Farzaneh Tamnanloo, Xiaoru Chen, Mélanie Tremblay, Christopher F. Rose.

Le guide La nutrition pour la cirrhose : une ressource éducative adéquate pour nos patients ?

Le guide La nutrition pour la cirrhose : une ressource éducative adéquate pour nos patients ?

Manila Sophasath, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Étude longitudinale: Suivi de l’état nutritionnel, de la qualité de vie et de la fonction musculaire des patients sur la liste d

Étude longitudinale: Suivi de l’état nutritionnel, de la qualité de vie et de la fonction musculaire des patients sur la liste d'attente pour une greffe de foie.

Amal Trigui, Joann Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Oral
La transplantation de microbiote fécal améliore la déficience neurologique chez les rats atteints d

La transplantation de microbiote fécal améliore la déficience neurologique chez les rats atteints d'une maladie hépatique chronique induite par la ligature du canal biliaire.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Neurological dysfunction is improved after faecal microbiota transplantation in rats with bile duct ligated-induced chronic liver disease.

Neurological dysfunction is improved after faecal microbiota transplantation in rats with bile duct ligated-induced chronic liver disease.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, André Marette, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Long-term screening for malnutrition, sarcopenia, and physical frailty in liver transplant recipients: a cross-sectional study.

Long-term screening for malnutrition, sarcopenia, and physical frailty in liver transplant recipients: a cross-sectional study.

Amal Trigui, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Nutritional education strategies for patients with cirrhosis: Evaluation of the Nutrition in cirrhosis guide.

Nutritional education strategies for patients with cirrhosis: Evaluation of the Nutrition in cirrhosis guide.

Manila Sophasath, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Neurological impairment in rats with bile duct ligated-induced chronic liver disease are improved after faecal microbiota transplantation.

Neurological impairment in rats with bile duct ligated-induced chronic liver disease are improved after faecal microbiota transplantation.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Nutritional education strategies for cirrhotic patients : Evaluation of a nutrition guide.

Nutritional education strategies for cirrhotic patients : Evaluation of a nutrition guide.

Manila Sophasath, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Longitudinal analysis of nutritional risk, muscle function and quality of life of patients with end stage liver disease waiting for liver transplantation.

Longitudinal analysis of nutritional risk, muscle function and quality of life of patients with end stage liver disease waiting for liver transplantation.

Amal Trigui, Joann Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Oral
Constant alcohol consumption exacerbates hepatic encephalopathy inducing neuronal cell loss in rats with chronic liver disease.

Constant alcohol consumption exacerbates hepatic encephalopathy inducing neuronal cell loss in rats with chronic liver disease.

Farzaneh Tamnanloo, Mélanie Tremblay, Christopher F. Rose.

Hyperuricemia as a risk factor for cognitive impairments in chronic liver disease: developing a new murine model.

Hyperuricemia as a risk factor for cognitive impairments in chronic liver disease: developing a new murine model.

Sydnée L'Écuyer, Alexandra Matesan, Farzaneh Tamnanloo, Mariana Oliveira, Mélanie Tremblay, Emmanuel Charbonney, Christopher F. Rose.

Évolution du risque nutritionnel, de la qualité de vie et de la fonction musculaire des patients en attente d’une transplantation hépatique : Étude longitudinale.

Amal Trigui, Joann Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

La transplantation de microbiote fécal améliore l’atteinte neurologique chez les rats avec une maladie hépatique chronique induite par la ligature du canal biliaire.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

OpenAccess
Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review.

Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review.

Amal Trigui, Christopher F. Rose, Chantal Bémeur.

Les effets de l’alcool éthylique sur le cervelet des rats cirrhotiques.

Les effets de l’alcool éthylique sur le cervelet des rats cirrhotiques.

Samia Cherkaoui, Farzaneh Tamnanloo, Xiaoru Chen, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Implication of Hypotension in the Pathogenesis of Cognitive Impairment and Brain Injury in Chronic Liver Disease.

Implication of Hypotension in the Pathogenesis of Cognitive Impairment and Brain Injury in Chronic Liver Disease.

Sydnée L'Écuyer, Emmanuel Charbonney, François Martin Carrier, Christopher F. Rose.

Oral

Longitudinal evolution of nutritional risk and muscle function of patients waiting for liver transplantation and the effect of early nutritional intervention following the transplantation

Amal Trigui, Joan Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Repeated ammonia-induced episodes of hepatic encephalopathy leads to neuronal cell loss in rats with chronic liver disease.

Repeated ammonia-induced episodes of hepatic encephalopathy leads to neuronal cell loss in rats with chronic liver disease.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Faecal microbiota transplantation improves neurological impairment in rats with chronic liver disease.

Faecal microbiota transplantation improves neurological impairment in rats with chronic liver disease.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Évolution de l’état nutritionnel, de la qualité de vie et de la fonction musculaire des patients en attente d’une transplantation hépatique.

Amal Trigui, Joan Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Oral

La transplantation de microbiote fécal améliore la déficience neurologique chez les rats atteints d'une maladie hépatique chronique induite par la ligature du canal biliaire.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher Rose.

Des épisodes d’encéphalopathie hépatique induits par l’ammoniaque mènent à des dommages cellulaires neuronaux chez les rats avec ligation de voie biliaire.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Oral

Évolution de l’état nutritionnel, de la qualité de vie et de la fonction musculaire des patients en attente d’une transplantation hépatique et l'effet d'une intervention nutritionnelle précoce après la transplantation sur ces paramètres.

Amal Trigui, Joan Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

OpenAccess
Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats.

Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats.

Mariana Macedo de Oliveira, Alexis Monnet-Aimard, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Evolution of nutritional risk, muscle function and quality of life of cirrhotic patients waiting for liver transplantation.

Evolution of nutritional risk, muscle function and quality of life of cirrhotic patients waiting for liver transplantation.

Amal Trigui, Joan Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Multiple hyperammonemia-induced episodes of HE leads to neuronal loss in rats with chronic liver disease.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Implication de l’acide urique dans la pathophysiologie de l’encéphalopathie hépatique.

Sydnée L'Écuyer, Mélanie Tremblay, Emmanuel Charbonney, Christopher F. Rose.

Oral

La transplantation de microbiote fécal améliore la déficience neurologique chez les rats atteints d'une maladie hépatique chronique induite par la ligature du canal biliaire.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher Rose.

Multiple hyperammonemia-induced episodes of HE leads to neuronal loss in rats with chronic liver disease.

Multiple hyperammonemia-induced episodes of HE leads to neuronal loss in rats with chronic liver disease.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Faecal microbiota transplantation improves neurological impairment in rats with bile-duct ligated induced chronic liver disease.

Faecal microbiota transplantation improves neurological impairment in rats with bile-duct ligated induced chronic liver disease.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Targeting glutamine synthetase in endothelial cells of the blood-brain barrier to treat hyperammonemia and hepatic encephalopathy.

Targeting glutamine synthetase in endothelial cells of the blood-brain barrier to treat hyperammonemia and hepatic encephalopathy.

Mariana M. Oliveira, Ole-Martin Fuskevåg, Mélanie Tremblay, Christopher Rose.

Impact of sex on muscle mass loss and hepatic encephalopathy in rats with chronic liver disease.

Impact of sex on muscle mass loss and hepatic encephalopathy in rats with chronic liver disease.

Mariana M. Oliveira, Alexis Monnet-Aimard, Cristina Bosoi, Mélanie Tremblay, Christopher Rose.

Évaluation de ressources éducatives en nutrition destinées aux patients atteints de cirrhose : Un projet en quatre volets.

Manila Sophasath, Yvette Mukaneza, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Oral
La transplantation de microbiote fécal améliore la déficience neurologique chez les rats atteints d

La transplantation de microbiote fécal améliore la déficience neurologique chez les rats atteints d'une maladie hépatique chronique induite par la ligature du canal biliaire.

Alexandre Bourgeois, Felix Veillette, Mariana Oliveira, Karine Dubois, Mélanie Tremblay, Chantal Bémeur, Christopher Rose.

Évolution de l’état nutritionnel, de la qualité de vie et de la fonction musculaire des patients en attente d’une transplantation hépatique.

Amal Trigui, Yvette Mukaneza, Mélanie Tremblay, Joann Maxwell, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Implication de l’acide urique dans la pathophysiologie de l’encéphalopathie hépatique.

Implication de l’acide urique dans la pathophysiologie de l’encéphalopathie hépatique.

Sydnée L'Écuyer, Mélanie Tremblay, Emmanuel Charbonney, Christopher F. Rose.

Ammonia-induced episodic HE leads to neuronal cell injury in bile-duct ligated rats

Ammonia-induced episodic HE leads to neuronal cell injury in bile-duct ligated rats

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Oral
The effect of early nutritional intervention on muscle mass following liver transplantation.

The effect of early nutritional intervention on muscle mass following liver transplantation.

Amal Trigui, Joann Maxwell, Geneviève Huard, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

OpenAccess
Renal dysfunction independently predicts muscle mass loss in patients following liver transplantation.

Renal dysfunction independently predicts muscle mass loss in patients following liver transplantation.

Mimosa Nguyen, Yvette Mukaneza, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

OpenAccess
Amino acids, ammonia, and hepatic encephalopathy.

Amino acids, ammonia, and hepatic encephalopathy.

Katerina Kroupina, Chantal Bémeur, Christopher F. Rose.

OpenAccess
Heretical thoughts into Hepatic Encephalopathy

Heretical thoughts into Hepatic Encephalopathy

Rajiv Jalan, Christopher F. Rose.

Optimisation de la masse musculaire grâce à une intervention nutritionnelle précoce chez les patients ayant reçu une transplantation hépatique.

Amal Trigui, Yvette Mukaneza, Mélanie Tremblay, Joan Maxwell, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Impact of sex on development of hepatic encephalopathy, sarcopenia and pathogenic factors in rats with chronic liver disease

Impact of sex on development of hepatic encephalopathy, sarcopenia and pathogenic factors in rats with chronic liver disease

Mariana M. Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

Episodic hepatic encephalopathy induces neuronal cell injury in rats with chronic liver disease

Episodic hepatic encephalopathy induces neuronal cell injury in rats with chronic liver disease

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Oral
Sex disparity on the development of HE: impact of ammonia and ROS in the development of brain edema and hepatic encephalopathy severity in BDL rats

Sex disparity on the development of HE: impact of ammonia and ROS in the development of brain edema and hepatic encephalopathy severity in BDL rats

Mariana M. Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Hepatic Encephalopathy: From Metabolic to Neurodegenerative.

Hepatic Encephalopathy: From Metabolic to Neurodegenerative.

Rafael Ochoa-Sanchez, Farzaneh Tamnanloo, Christopher F. Rose.

Evaluation of the Nutrition in Cirrhosis Guide : an implementation study.

Evaluation of the Nutrition in Cirrhosis Guide : an implementation study.

Manila Sophasath, Yvette Mukaneza, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, C. Bémeur.

Role of sex on the development of sarcopenia and ammonia metabolism in bile-duct ligated rats.

Role of sex on the development of sarcopenia and ammonia metabolism in bile-duct ligated rats.

Mariana M. Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

Obese-induced brain sphingolipid dysregulation in bile-duct ligated rats accelerates and exacerbates hepatic encephalopathy.

Obese-induced brain sphingolipid dysregulation in bile-duct ligated rats accelerates and exacerbates hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Régime hyperprotéiné dans l'encéphalopathie hépatique : précipitant ou protecteur ?

Katerina Kroupina, Karine Dubois, Mélanie Tremblay, Christopher Rose.

Implication de l’acide urique dans le développement des déficits cognitifs associés à l’encéphalopathie hépatique.

Sydnée L'Écuyer, Karine Dubois, Mélanie Tremblay, Emmanuel Charbonney, Christopher Rose.

Sex impacts muscle loss and ammonia metabolism in rats with chronic liver disease.

Mariana M. Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

Implication de l’acide urique dans le développement des déficits cognitifs associés à l’encéphalopathie hépatique.

Sydnée L'Écuyer, Karine Dubois, Mélanie Tremblay, Emmanuel Charbonney, Christopher Rose.

Ammonia-induced episodic HE leads to neuronal cell injury in bile-duct ligated rats.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

L’effet d’une intervention nutritionnelle précoce sur la masse musculaire chez les patients ayant reçu une transplantation hépatique.

Amal Trigui, Yvette Mukaneza, Mélanie Tremblay, Joann Maxwell, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Le guide de nutrition pour la cirrhose : quel est son effet chez les gens atteints de maladie hépatique chronique et leurs proches aidants?

Manila Sophasath, Yvette Mukaneza, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Ammonia-induced episodic HE leads to neuronal cell injury in bile-duct ligated rats.

Ammonia-induced episodic HE leads to neuronal cell injury in bile-duct ligated rats.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

La barrière hémato-encéphalique lors d

La barrière hémato-encéphalique lors d'encéphalopathie hépatique épisodique.

Mihai Alexandru Popovici, Farzaneh Tamnanloo, Mélanie Tremblay, Christopher F. Rose.

Régime hyperprotéiné dans l

Régime hyperprotéiné dans l'encéphalopathie hépatique : précipitant ou protecteur ?

Katerina Kroupina, Karine Dubois, Mélanie Tremblay, Christopher F. Rose.

Implication de l’acide urique dans le développement des déficits cognitifs associés à l’encéphalopathie hépatique.

Implication de l’acide urique dans le développement des déficits cognitifs associés à l’encéphalopathie hépatique.

Sydnée L'Écuyer, Karine Dubois, Mélanie Tremblay, Emmanuel Charbonney, Christopher F. Rose.

L’effet d’une intervention nutritionnelle précoce sur la masse musculaire chez les patients ayant reçu une transplantation hépatique.

L’effet d’une intervention nutritionnelle précoce sur la masse musculaire chez les patients ayant reçu une transplantation hépatique.

Amal Trigui, Yvette Mukaneza, Mélanie Tremblay, Joann Maxwell, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Online-based psychometric assessment battery as a predictive test for Hepatic Encephalopathy in cirrhotic patients.

Online-based psychometric assessment battery as a predictive test for Hepatic Encephalopathy in cirrhotic patients.

Silícia Ane Tres, Mélanie Tremblay, Yvette Mukaneza, Christopher F. Rose.

Effects of sex on liver disease: impact on sarcopenia and ammonia metabolism in bile-duct ligated rats.

Effects of sex on liver disease: impact on sarcopenia and ammonia metabolism in bile-duct ligated rats.

Mariana M. Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

Repeated hyperammonemic insults leads to irreversible brain injury in bile-duct ligated rats.

Repeated hyperammonemic insults leads to irreversible brain injury in bile-duct ligated rats.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Dysregulation of sphingolipids in obese-cirrhotic rats aggravates hepatic encephalopathy.

Dysregulation of sphingolipids in obese-cirrhotic rats aggravates hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Sex disparity in the development of brain edema and hepatic encephalopathy severity in BDL rats.

Sex disparity in the development of brain edema and hepatic encephalopathy severity in BDL rats.

Mariana Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

The Nutrition in Cirrhosis Guide: a useful education tool for in people suffering from chronic liver disease and their caregivers?

The Nutrition in Cirrhosis Guide: a useful education tool for in people suffering from chronic liver disease and their caregivers?

Manila Sophasath, Yvette Mukaneza, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

The Nutrition in Cirrhosis Guide: Potential beneficial effects in cirrhotic patients and caregivers.

The Nutrition in Cirrhosis Guide: Potential beneficial effects in cirrhotic patients and caregivers.

Manila Sophasath, Yvette Mukaneza, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Le Guide de nutrition pour la cirrhose : effets potentiellement bénéfiques chez les patients atteints de maladie hépatique chronique et leurs proches aidants.

Manila Sophasath, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Oral
Les métaux lourds et l’encéphalopathie hépatique.

Les métaux lourds et l’encéphalopathie hépatique.

Mihai Alexandru Popovici, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Elevated Serum Liver-Type Fatty Acid Binding Protein Levels in Non-acetaminophen Acute Liver Failure Patients with Organ Dysfunction.

Elevated Serum Liver-Type Fatty Acid Binding Protein Levels in Non-acetaminophen Acute Liver Failure Patients with Organ Dysfunction.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, U. S. Acute Liver Failure Study Group.

OpenAccess
Bile-duct ligation renders the brain susceptible to hypotension induced neuronal degeneration: implications of ammonia.

Bile-duct ligation renders the brain susceptible to hypotension induced neuronal degeneration: implications of ammonia.

Marc-André Clément, Cristina R. Bosoi, Mariana M. Oliveira, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral
Redefining poor prognostic criteria for acetaminophen-induced acute liver failure using regeneration and cell-death linked miRNA signatures

Redefining poor prognostic criteria for acetaminophen-induced acute liver failure using regeneration and cell-death linked miRNA signatures

Oliver Tavabie, Constantine J. Karvellas, SIamak Salehi, Jaime Speiser, Christopher F. Rose, Krishna Menon, Andreas Prachalias, Michael A. Heneghan, Kosh Agarwal, William M. Lee, Mark J. McPhail, Varuna Aluvihare, U. S. Acute Liver Failure Study Group.

OpenAccess
Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy.

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy.

Christopher F. Rose, Piero Amodio, Jasmohan S. Bajaj, Radha Krishan Dhiman, Sara Montagnese, Simon D. Taylor-Robinson, Hendrik Vilstrup, Rajiv Jalan.

Stroop EncephalApp as a predictive test for overt Hepatic Encephalopathy in cirrhotic patients.

Silicia A. Très, Mélanie Tremblay, Yvette Mukaneza, Christopher F. Rose.

Outcomes of sarcopenic obesity and metabolic syndrome in liver transplant patients.

Outcomes of sarcopenic obesity and metabolic syndrome in liver transplant patients.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher Rose, Chantal Bémeur.

New insights on the impact of sex on chronic liver disease and hepatic encephalopathy.

New insights on the impact of sex on chronic liver disease and hepatic encephalopathy.

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Diabetes is associated to the development of hepatic encephalopathy in cirrhotic patients.

Diabetes is associated to the development of hepatic encephalopathy in cirrhotic patients.

Cristina R. Bosoi, Corina Cerlat, Mimosa Nguyen, Mélanie Tremblay, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Diabetes is associated to the development of hepatic encephalopathy in cirrhotic patients.

Corina Cerlat, Cristina R. Bosoi, Mimosa Nguyen, Mélanie Tremblay, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future

Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future

Chantal Bémeur, Christopher F. Rose.

Sarcopenic obesity and metabolic syndrome: what is the impact in the context of liver transplantation?

Sarcopenic obesity and metabolic syndrome: what is the impact in the context of liver transplantation?

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

OpenAccess
An Investigation of PS‐b‐PEO Polymersomes for the Oral Treatment and Diagnosis of Hyperammonemia

An Investigation of PS‐b‐PEO Polymersomes for the Oral Treatment and Diagnosis of Hyperammonemia

Simon Matoori, Yinyin Bao, Aaron Schmidt, Eric J. Fischer, Rafael Ochoa-Sanchez, Mélanie Tremblay, Mariana M. Oliveira, Christopher F. Rose, Jean‐Christophe Leroux.

OpenAccess
The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis

The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis

Mathilde Mouchiroud, Étienne Camiré, Manal Aldow, Alexandre Caron, Éric Jubinville, Laurie Turcotte, Inès Kaci, Marie-Josée Beaulieu, Christian Roy, Sébastien M. Labbé, Thibault V. Varin, Yves Gélinas, Jennifer Lamothe, Jocelyn Trottier, Patricia L. Mitchell, Frédéric Guénard, William T. Festuccia, Philippe Joubert, Christopher F. Rose, Constantine J. Karvellas, Olivier Barbier, Mathieu C. Morissette, André Marette, Mathieu Laplante.

OpenAccess
Proceedings from the 2018 Canadian Association for the Study of the Liver Single Topic Conference – Decompensated Cirrhosis: from clinic to transplant

Proceedings from the 2018 Canadian Association for the Study of the Liver Single Topic Conference – Decompensated Cirrhosis: from clinic to transplant

Victor Dong, Maxime Gosselin, Nishita Jagarlamudi, Beverley Kok, Mark G. Swain, Jasmohan S. Bajaj, Juan G. Abraldes, Vladimir Marquez, R. Todd Stravitz, Aldo J. Montano-Loza, Manuela Merli, Phil Wong, Amanda Brisebois, Punetta Tandon, Julia Wendon, Scott L. Nyberg, François M. Carrier, Michael R. Lucey, Florence Wong, Jordan J. Feld, Constantine J. Karvellas, Christopher F. Rose, Julien Bissonnette.

The attenuation of hyperammonemia by genetically engineered E. coli Nissle counters memory deficits in an experimental model of cirrhosis and hepatic encephalopathy.

The attenuation of hyperammonemia by genetically engineered E. coli Nissle counters memory deficits in an experimental model of cirrhosis and hepatic encephalopathy.

Rafael Ochoa-Sanchez, Alexis Monnet, Farzaneh Tamnanloo, Mariana M. Oliveira, Mélanie Tremblay, Mylene Perreault, Bill Querbes, Caroline Kurtz, Christopher F. Rose.

Uncovering the impact of sex-based differences in a rat model of chronic liver disease and hepatic encephalopathy.

Uncovering the impact of sex-based differences in a rat model of chronic liver disease and hepatic encephalopathy.

Mariana Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

Developing a New Animal Model of Episodic Hepatic Encephalopathy.

Developing a New Animal Model of Episodic Hepatic Encephalopathy.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Obesity accelerates and exacerbates neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Obesity accelerates and exacerbates neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Alexis Monnet, Farzaneh Tamnanloo, Mariana M. Oliveira, Mylene Perreault, Bill Querbes, Caroline B. Kurtz, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Genetically Engineered E. coli Nissle attenuates hyperammonemia and improves memory in an experimental model of cirrhosis and hepatic encephalopathy.

Genetically Engineered E. coli Nissle attenuates hyperammonemia and improves memory in an experimental model of cirrhosis and hepatic encephalopathy.

Rafael Ochoa-Sanchez, Alexis Monnet, Farzaneh Tamnanloo, Mariana M. Oliveira, Mélanie Tremblay, Mylene Perreault, Bill Querbes, Caroline B. Kurtz, Christopher F. Rose.

Oral
Uncovering sex-based differences in a rat model of chronic liver disease and hepatic encephalopathy

Uncovering sex-based differences in a rat model of chronic liver disease and hepatic encephalopathy

Mariana M. Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

Sarcopenia Pre- and Post-liver Transplantation Implication for Hepatic Encephalopathy.

Sarcopenia Pre- and Post-liver Transplantation Implication for Hepatic Encephalopathy.

Mimosa Nguyen, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Characterization of a novel animal model of episodic hepatic encephalopathy.

Characterization of a novel animal model of episodic hepatic encephalopathy.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Obesity-induced cirrhosis results in more complex and poor neurological performance related to hepatic encephalopathy in cirrhosis.

Obesity-induced cirrhosis results in more complex and poor neurological performance related to hepatic encephalopathy in cirrhosis.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Glutamine synthetase in the blood-brain barrier: role in hindering hyperammonemia-induced neurotoxicity?

Glutamine synthetase in the blood-brain barrier: role in hindering hyperammonemia-induced neurotoxicity?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.

The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.

Mathilde Mouchiroud, Étienne Camiré, Manal Aldow, Alexandre Caron, Éric Jubinville, Laurie Turcotte, Inès Kaci, Marie-Josée Beaulieu, Christian Roy, Sébastien M. Labbé, Thibault V. Varin, Yves Gélinas, Jennifer Lamothe, Jocelyn Trottier, Patricia L. Mitchell, Frédéric Guénard, William T. Festuccia, Philippe Joubert, Christopher F. Rose, Constantine J. Karvellas, Olivier Barbier, Mathieu C. Morissette, André Marette, Mathieu Laplante.

Characterization of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Characterization of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Malnutrition in chronic liver disease: Implications for quality of life and hepatic encephalopathy

Malnutrition in chronic liver disease: Implications for quality of life and hepatic encephalopathy

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher Rose, Chantal Bémeur.

Sarcopenia in the context of liver transplantation: What is the prognosis?

Sarcopenia in the context of liver transplantation: What is the prognosis?

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher Rose, Chantal Bémeur.

Uncovering the protective mechanism of the BBB against ammonia neurotoxicity.

Uncovering the protective mechanism of the BBB against ammonia neurotoxicity.

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Association entre la sarcopénie et le pronostic des patients cirrhotiques dans le contexte de la transplantation hépatique.

Association entre la sarcopénie et le pronostic des patients cirrhotiques dans le contexte de la transplantation hépatique.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Évaluation d’un guide éducatif en nutrition destiné aux gens atteints de maladie hépatique chronique.

Évaluation d’un guide éducatif en nutrition destiné aux gens atteints de maladie hépatique chronique.

Manila Sophasath, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Sarcopenia is associated with a worst prognosis in cirrhotic patients in the context of liver transplantation.

Sarcopenia is associated with a worst prognosis in cirrhotic patients in the context of liver transplantation.

Mimosa Nguyen, Mélanie Tremblay, An Tang, Christopher F. Rose, Chantal Bémeur.

Oral
The association between liver type fatty acid binding protein (FABP1) serum levels and clinical outcomes in patients with non-acetaminophen acute liver failure: a cohort study.

The association between liver type fatty acid binding protein (FABP1) serum levels and clinical outcomes in patients with non-acetaminophen acute liver failure: a cohort study.

Constantine Karvellas, Jaime Speiser, William M. Lee, Mélanie Tremblay, Christopher F. Rose.

The association between sarcopenia and the prognosis of cirrhotic patients in liver transplantation.

The association between sarcopenia and the prognosis of cirrhotic patients in liver transplantation.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Impact of gender on development of chronic liver disease and hepatic encephalopathy following bile duct ligation.

Impact of gender on development of chronic liver disease and hepatic encephalopathy following bile duct ligation.

Mariana Oliveira, Mélanie Tremblay, Christopher Rose.

Evaluate the efficiency of Rifaximin treatment in a bile-duct ligated model of cirrhosis.

Evaluate the efficiency of Rifaximin treatment in a bile-duct ligated model of cirrhosis.

Grégory Petrazzo, Mariana M. Oliveira, Mélanie Tremblay, Christopher F. Rose.

Association entre la sarcopénie et le pronostic des patients cirrhotiques dans le contexte de la transplantation hépatique.

Association entre la sarcopénie et le pronostic des patients cirrhotiques dans le contexte de la transplantation hépatique.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Genetically Engineered E. coli nissle Attenuates Hyperammonemia in Two Experimental Models of Hepatic Encephalopathy.

Genetically Engineered E. coli nissle Attenuates Hyperammonemia in Two Experimental Models of Hepatic Encephalopathy.

Rafael Ochoa-Sanchez, Mariana M. Oliveira, Grégory Petrazzo, Yossi Dagon, Kip West, Lauren Renaud, Caroline Kurtz, Christopher F. Rose.

Genetically Engineered E. coli nissle Attenuates Hyperammonemia in Two Experimental Models of Hepatic Encephalopathy.

Genetically Engineered E. coli nissle Attenuates Hyperammonemia in Two Experimental Models of Hepatic Encephalopathy.

Rafael Ochoa-Sanchez, Mariana Oliveira, Grégory Petrazzo, Yossi Dagon, Kip West, Lauren Renaud, Caroline Kurtz, Christopher F. Rose.

OpenAccess
Progressive resistance training prevents loss of muscle mass and strength in bile duct ligated rats.

Progressive resistance training prevents loss of muscle mass and strength in bile duct ligated rats.

Mariana M. Oliveira, Christopher F. Rose, Luise Aamann, Rafael Ochoa-Sanchez, Mariana Oliveira, Mélanie Tremblay, Chantal Bémeur, Gitte Dam, Hendrik Vilstrup, Niels Kristian Aagaard, Christopher Rose.

OpenAccess
Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.

Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.

Rafael Ochoa-Sanchez, Christopher F. Rose.

Nutritional status in patients with chronic liver disease: Impact on hepatic encephalopathy and health-related quality of life.

Nutritional status in patients with chronic liver disease: Impact on hepatic encephalopathy and health-related quality of life.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis.

Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis.

Rahima A. Bhanji, Carlos Moctezuma-Velazquez, Andres Duarte-Rojo, Maryam Ebadi, Sunita Ghosh, Christopher Rose, Aldo J. Montano-Loza.

Diagnosis and Management of Hepatic Encephalopathy: A Case-based Guide

Diagnosis and Management of Hepatic Encephalopathy: A Case-based Guide

Julien Bissonnette, Christopher F. Rose.

Impact de la sarcopénie lors de la transplantation hépatique : une étude rétrospective en cours.

Impact de la sarcopénie lors de la transplantation hépatique : une étude rétrospective en cours.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Oral
Evaluate the efficiency of rifaximin treatment in a bile-duct ligated model of hepatic encephalopathy.

Evaluate the efficiency of rifaximin treatment in a bile-duct ligated model of hepatic encephalopathy.

Grégory Petrazzo, Mariana M. Oliveira, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Alcohol accelerates hepatic encephalopathy in a rat bile duct ligation model.

Alcohol accelerates hepatic encephalopathy in a rat bile duct ligation model.

Xiaoru Chen, Mariana Oliveira, Grégory Petrazzo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher Rose.

OpenAccess
Assessment of the spectrum of hepatic encephalopathy: A multicenter study.

Assessment of the spectrum of hepatic encephalopathy: A multicenter study.

Bradley Reuter, Kara Walter, Julien Bissonnette, Michael D. Leise, Jennifer Lai, Puneeta Tandon, Patrick S. Kamath, Scott W. Biggins, Christopher F. Rose, James B. Wade, Jasmohan S. Bajaj.

Impact de la sarcopénie lors de la transplantation hépatique : une étude rétrospective en cours.

Impact de la sarcopénie lors de la transplantation hépatique : une étude rétrospective en cours.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Impact de l

Impact de l'état nutritionnel sur la qualité de vie et l'encéphalopathie hépatique lors de maladies chroniques du foie.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Obesity exacerbates the neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Obesity exacerbates the neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Christopher F. *Rose, Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Christopher F. Rose.

Oral
Glutamine synthetase in the blood-brain barrier: targeting endothelial cells for the treatment of hepatic encephalopathy?

Glutamine synthetase in the blood-brain barrier: targeting endothelial cells for the treatment of hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Nutritional status, hepatic encephalopathy and health-related quality of life in patients with chronic liver disease.

Nutritional status, hepatic encephalopathy and health-related quality of life in patients with chronic liver disease.

Christopher F. *Rose, Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Impact de l’exercice sur la protection du cerveau lors de maladie hépatique chronique expérimentale.

Charlène Blanchette, Luise Aamann, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Nouveau modèle d’encéphalopathie hépatique épisodique due à la cirrhose.

Kim Phat Pham, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Caractérisation de la microglie dans un modèle expérimental du syndrome de leigh version canadienne française.

Raluca Ticala, Mélanie Tremblay, Christopher F. Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Nutritional status, hepatic encephalopathy and health-related quality of life in patients with chronic liver disease.

Nutritional status, hepatic encephalopathy and health-related quality of life in patients with chronic liver disease.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Can We Accurately Assess the Spectrum of Hepatic Encephalopathy (HE) Stages? A Multi-Center Initiative using Standardized Simulated Patients.

Can We Accurately Assess the Spectrum of Hepatic Encephalopathy (HE) Stages? A Multi-Center Initiative using Standardized Simulated Patients.

Jasmohan S. Bajaj, Bradley Reuter, Kara Walter, Scott W. Biggins, Julien Bissonnette, Christopher F. Rose, Jennifer C. Lai, Michael D. Leise, Patrick S. Kamath, Puneeta Tandon, James Wade.

Obesity exacerbates the neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Obesity exacerbates the neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Glutamine synthetase in endothelial cells of the blood-brain barrier: role in protecting the brain from hyperammonemia-induced neurotoxicity?

Glutamine synthetase in endothelial cells of the blood-brain barrier: role in protecting the brain from hyperammonemia-induced neurotoxicity?

Mariana Macedo de Oliveira, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.

The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, U. S. Acute Liver Failure Study Group.

Oral

Liposome-supported peritoneal dialysis for the treatment of hyperammonemia-associated encephalopathy.

Valentina Agostoni, G. Giacalone, Cristina R. Bosoi, Christopher F. Rose, Jean-Christophe Leroux.

OpenAccess
Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

José I. Fortea, Alexander Zipprich, Carolina Fernandez-Mena, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Juan Bañares, Belén Rodríguez-Sánchez, Emilia Cercenado, Marc-André Clément, Christopher F. Rose, Rafael Bañares, Javier Vaquero, Cristina Ripoll.

Glutamine synthetase in endothelial cells of the blood-brain barrier: role in preventing protecting the brain in hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Oral

Characterization of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Christopher F. Rose.

Oral
Hepatic encephalopathy and health-related quality of life among cirrhotic patients: Scope of nutritional status.

Hepatic encephalopathy and health-related quality of life among cirrhotic patients: Scope of nutritional status.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher Rose, Chantal Bémeur.

Glutamine synthetase in endothelial cells of the blood-brain barrier: new target for the treatment of hepatic encephalopathy?

Glutamine synthetase in endothelial cells of the blood-brain barrier: new target for the treatment of hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher Rose.

Nouveau modèle d’encéphalopathie hépartique épisodique due à la cirrhose.

Nouveau modèle d’encéphalopathie hépartique épisodique due à la cirrhose.

Kim Phat Pham, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Impact de l’état nutritionnel sur l’encéphalopathie hépatique et la qualité de vie chez les patients atteints de maladie chronique du foie : Résultats préliminaires d’une étude prospective.

Impact de l’état nutritionnel sur l’encéphalopathie hépatique et la qualité de vie chez les patients atteints de maladie chronique du foie : Résultats préliminaires d’une étude prospective.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Oral
Impact de l

Impact de l'état nutritionnel sur l'encéphalopathie hépatique et la qualité de vie chez les patients atteints de maladie chronique du foie: résultats préliminaires d'une étude prospective.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher Rose, Chantal Bémeur.

Comparaison d’outils d’évaluation nutritionnelle lors de cirrhose.

Comparaison d’outils d’évaluation nutritionnelle lors de cirrhose.

Annie Lamoussenerie, Cassandra Picinbono-Larose, Mélanie Tremblay, Thierry Cresson, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

New animal model of obesity and chronic liver disease to provide insights on non-alcoholic liver disease-induced hepatic encephalopathy.

New animal model of obesity and chronic liver disease to provide insights on non-alcoholic liver disease-induced hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Marcos Ocana-Sanchez, Christopher F. Rose.

Glutamine synthetase in endothelial cells of the blood-brain barrier: less but not insignificant?

Glutamine synthetase in endothelial cells of the blood-brain barrier: less but not insignificant?

Christopher F. *Rose, Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

Cristina R. Bosoi, Mariana M. Oliveira, Rafael Ochoa-Sanchez, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose, Chantal Bémeur.

OpenAccess
Ammonia toxicity: from head to toe?

Ammonia toxicity: from head to toe?

Srinivasan Dasarathy, Rajeshwar P. Mookerjee, Veronika Rackayova, Vinita Rangroo Thrane, Balasubramaniyan Vairappan, Peter Ott, Christopher F. Rose.

In reply: Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

In reply: Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

U. S. Acute Liver Failure Study Group, Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, U. S. Acute Liver Failure Study Group.

Nutritional status assessment in patients with chronic liver disease: a pilot study.

Nutritional status assessment in patients with chronic liver disease: a pilot study.

Annie Lamoussenerie, Cassandra Picinbono-Larose, Mélanie Tremblay, Catherine Demers, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Development of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Development of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Marcos Ocana-Sanchez, Christopher F. Rose.

Brain-type Fatty Acid Binding Protein (FABP7) and Neurological Complications of Acetaminophen-induced Acute Liver Failure.

Brain-type Fatty Acid Binding Protein (FABP7) and Neurological Complications of Acetaminophen-induced Acute Liver Failure.

Constantine Jason Karvellas, Jaime Lynn Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose.

Elevated Liver Fatty Acid Binding Protein (FABP1) Serum Levels Improve Prognostic Discrimination of King’s College Criteria and the ALSFG Index in Acetaminophen-induced Acute Liver Failure: A Nested Case Control Study.

Elevated Liver Fatty Acid Binding Protein (FABP1) Serum Levels Improve Prognostic Discrimination of King’s College Criteria and the ALSFG Index in Acetaminophen-induced Acute Liver Failure: A Nested Case Control Study.

Constantine Jason Karvellas, Jaime Lynn Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose.

Oral
Effects of anaerobic exercise in muscle mass optimization in bile duct ligated rats.

Effects of anaerobic exercise in muscle mass optimization in bile duct ligated rats.

Mariana Oliveira, Christopher Rose, Luise Aamann, Rafael Ochoa-Sanchez, Mariana M. Oliveira, Mélanie Tremblay, Chantal Bémeur, Gitte Dam, Hendrik Vilstrup, Niels Kristian Aagaard, Christopher F. Rose.

Impact of nutritional status on hepatic encephalopathy and quality of life in patients with chronic liver disease: preliminary results of a prospective study.

Impact of nutritional status on hepatic encephalopathy and quality of life in patients with chronic liver disease: preliminary results of a prospective study.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Demers, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Oral
Skeletal muscle abnormalities increase the risk of overt hepatic encephalopathy and hyperammonemia in patients with cirrhosis.

Skeletal muscle abnormalities increase the risk of overt hepatic encephalopathy and hyperammonemia in patients with cirrhosis.

Rahima A. Bhanji, Andres Duarte-Rojo, Christopher Rose, Aldo J. Montano-Loza.

Oral
Oral Ornithine Phenylacetate Attenuates Muscle Mass Loss and Prevents Hepatic Encephalopathy in BDL Rats.

Oral Ornithine Phenylacetate Attenuates Muscle Mass Loss and Prevents Hepatic Encephalopathy in BDL Rats.

Marc-André Clément, Cristina R. Bosoi, Mariana Oliveira, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose.

Oral
Glutamine synthetase in endothelial cells of the blood-brain barrier: less but not insignificant ?

Glutamine synthetase in endothelial cells of the blood-brain barrier: less but not insignificant ?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Glutamine synthetase in endothelial cells of the blood-brain barrier: new target for the treatment of hepatic encephalopathy?

Glutamine synthetase in endothelial cells of the blood-brain barrier: new target for the treatment of hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Oral

Liver type fatty acid binding protein (FABP1) levels improve performance of prognostic models in acetaminophen induced acute liver failure.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Elaine M. Leslie, Christopher F. Rose.

Oral

Nouveau modèle d’encéphalopathie hépatique épisodique due à la cirrhose.

Kim Phat Pham, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Brain-FABP serum levels and clinical outcomes in acetaminophen-induced acute liver failure.

Constantine Karvellas, Jaime Speiser, Mélanie Tremblay, William Lee, Christopher Rose.

Oral
Elevated Liver Fatty Acid Binding protein serum levels improve prognostic discrimination of King’s College Criteria and the ALFSG index in acetaminophen-induced acute liver failure: a case control study.

Elevated Liver Fatty Acid Binding protein serum levels improve prognostic discrimination of King’s College Criteria and the ALFSG index in acetaminophen-induced acute liver failure: a case control study.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Elaine M. Leslie, Christopher F. Rose.

The association between Brain Fatty Acid Binding protein serum levels with survival and intracranial hypertension in acetaminophen-induced acute liver failure patients: a case control study.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Gurnit Kaur, Elaine M. Leslie, Christopher Rose, US Acute Liver Failure Study Group.

The role of the blood-brain barrier in ammonia homeostasis: targeting endothelial cells for the treatment of hepatic encephalopathy.

The role of the blood-brain barrier in ammonia homeostasis: targeting endothelial cells for the treatment of hepatic encephalopathy.

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Evaluation of nutritional status in patients with chronic liver disease: a pilot study.

Evaluation of nutritional status in patients with chronic liver disease: a pilot study.

Annie Lamoussenerie, Mélanie Tremblay, Thierry Cresson, An Tang, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Évaluation de l

Évaluation de l'état nutritionnel lors de cirrhose.

Annie Lamoussenerie, Mélanie Tremblay, Thierry Cresson, An Tang, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Developing a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Developing a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Mariana Oliveira, Cristina Bosoi, Marc-André Clément, Christopher F. Rose.

Oral
Beneficial effects of ornithine phenylacetate to attenuate muscle mass loss and to prevent hepatic encephalopathy in experimental cirrhosis.

Beneficial effects of ornithine phenylacetate to attenuate muscle mass loss and to prevent hepatic encephalopathy in experimental cirrhosis.

Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. *Rose.

Évaluation de l

Évaluation de l'état nutritionnel lors de cirrhose.

Annie Lamoussenerie, Mélanie Tremblay, Thierry Cresson, An Tang, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Oral
Ornithine phenylacetate attenuates loss of muscle mass and improves hepatic encephalopathy in bile-duct ligated rats.

Ornithine phenylacetate attenuates loss of muscle mass and improves hepatic encephalopathy in bile-duct ligated rats.

Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabrie Ten Have, Nicholaas Deutz, Christopher F. Rose.

Oral
Cirrhotic patients with sarcopenia and sarcopenic obesity have an increased risk of hyperammonemia and hepatic encephalopathy.

Cirrhotic patients with sarcopenia and sarcopenic obesity have an increased risk of hyperammonemia and hepatic encephalopathy.

Aldo Montano-Loza, Andres Duarte-Rojo, Rahima Bhanji, Christopher F. Rose.

Estudio del efecto de la enoxaparina sobre la cirrosis e hipertensión portal experimental.

Jose Ignacio Fortea, Alexander Zipprich, Carolina Mena Fernandez, Christopher F. Rose, Juan Bañares, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Marc-André Clément, Javier Vaquero, Rafael Bañares, Cristina Ripoll.

Oral
Minimal hepatic encephalopathy renders the brain susceptible to hypotension-induced neuronal cell loss in BDL rats.

Minimal hepatic encephalopathy renders the brain susceptible to hypotension-induced neuronal cell loss in BDL rats.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Leucine et exercices : bénéfique lors d'encéphalopathie expérimentale.

Corine Fontaine, Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Oral

Neuroinflammation et activation microgliale chez des rats cirrhotiques soumis à une hypotension.

Maxime Hovington, Marc-André Clément, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Valentina Agostoni, Soo Hyeon Lee, Vincent Forster, Meriam Kabbaj, Cristina Bosoi, Mélanie Tremblay, Matthias Zadory, Christopher F. Rose, Jean-Christophe Leroux.

OpenAccess
Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Chantal Bémeur, Cristina Cudalbu, Gitte Dam, Alexander S. Thrane, Arthur J. L. Cooper, Christopher F. Rose.

Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.

Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.

Rune Gangsøy Kristiansen, Christopher F. Rose, Lars Marius Ytrebø.

OpenAccess
Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure.

Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure.

Geir I. Nedredal, Kjetil Elvevold, Marcio F. Chedid, Lars M. Ytrebø, Christopher F. Rose, Sambit Sen, Bård Smedsrød, Rajiv Jalan, Arthur Revhaug.

Sarcopenia and Sarcopenic-Obesity are Associated with Hyperammonemia and Increased Risk of Hepatic Encephalopathy in Cirrhotics.

Sarcopenia and Sarcopenic-Obesity are Associated with Hyperammonemia and Increased Risk of Hepatic Encephalopathy in Cirrhotics.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Rahima A. Bhanji, Christopher F. Rose.

Enoxaparin treatment does not ameliorate liver fibrosis or portal hypertension in experimental models of cirrhosis in rats.

Enoxaparin treatment does not ameliorate liver fibrosis or portal hypertension in experimental models of cirrhosis in rats.

Jose Ignacio Fortea, Alexander Zipprich, Carolina-Mena Fernandez, Christopher F. Rose, Juan Bañares, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Marc-André Clément, Javier Vaquero, Rafael Bañares, Cristina Ripoll.

Oral
Minimal hepatic encephalopathy leads to hypotension-induced neuronal cell loss in BDL rats.

Minimal hepatic encephalopathy leads to hypotension-induced neuronal cell loss in BDL rats.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Long term oral treatment of ornithine phenylacetate increases lean mass and attenuates brain edema in bile-duct ligated rats.

Long term oral treatment of ornithine phenylacetate increases lean mass and attenuates brain edema in bile-duct ligated rats.

Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabrie Ten Have, Nicolaas E. P. Deutz, Christopher F. Rose.

Liposome-Supported Peritoneal Dialysis in the Treatment of Severe Hyperammonemia.

Valentina Agostoni, Vincent Forster, Cristina Bosoi, Mélanie Tremblay, Christopher Rose, Jean-Christophe Leroux.

Impact d

Impact d'un stress inflammatoire et nutritionnel dans un modèle cellulaire d'acidose lactique.

Rafaela Almeida, Mélanie Tremblay, Christopher Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Cirrhotic patients with sarcopenia and sarcopenic-obesity have an increased risk of hyperammonemia and hepatic encephalopathy.

Cirrhotic patients with sarcopenia and sarcopenic-obesity have an increased risk of hyperammonemia and hepatic encephalopathy.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Rahima A. Bhanji, Christopher F. Rose.

Impact d’un stress de type inflammatoire et nutritionnel dans un modèle cellulaire d’acidose lactique.

Impact d’un stress de type inflammatoire et nutritionnel dans un modèle cellulaire d’acidose lactique.

Rafaela Almeida, Mélanie Tremblay, Christopher Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral
Impact d

Impact d'un stress inflammatoire et nutritionnel dans un modèle cellulaire d'acidose lactique.

Rafaela Almeida, Mélanie Tremblay, Christopher Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Oral
Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Sarcopenia and Myosteatosis Increase the Risk of Hepatic Encephalopathy in Cirrhotic Patients.

Sarcopenia and Myosteatosis Increase the Risk of Hepatic Encephalopathy in Cirrhotic Patients.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Christopher F. Rose.

Muscle mass optimization prevents experimental hepatic encephalopathy.

Muscle mass optimization prevents experimental hepatic encephalopathy.

Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Bile-ligated rats are susceptible to hypotension-induced neuronal cell loss: implications for persisting neurological complications following liver transplantation.

Bile-ligated rats are susceptible to hypotension-induced neuronal cell loss: implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Reply to: "Pivotal preclinical trial of the spheroid reservoir bioartificial liver".

Reply to: "Pivotal preclinical trial of the spheroid reservoir bioartificial liver".

Jaime M. Glorioso, Shennen A. Mao, Brian Rodysill, Taufic Mounajjed, Walter K. Kremers, Faysal Elgilani, Raymond D. Hickey, Hakon Haugaa, Christopher F. Rose, Bruce Amiot, Scott L. Nyberg.

Effet du stress oxydatif et de l'ammoniaque sur la perméabilité de la barrière hémato-encéphalique dans la maladie de foie chronique.

Valérie Boucher, Mélanie Tremblay, Christopher F. Rose.

Pivotal preclinical trial of the spheroid reservoir bioartificial liver.

Pivotal preclinical trial of the spheroid reservoir bioartificial liver.

Jaime M. Glorioso, Shennen A. Mao, Brian Rodysill, Taufic Mounajjed, Walter K. Kremers, Faysal Elgilani, Raymond D. Hickey, Hakon Haugaa, Christopher F. Rose, Bruce Amiot, Scott L. Nyberg.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Caractérisation d

Caractérisation d'un modèle cellulaire de stress de type inflammatoire et nutritionnel lors du syndrome de leigh version canadienne française.

Rafaela Almeida, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur, Consortium de l'acidose lactique.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased BBB permeability via NKCC1.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased BBB permeability via NKCC1.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral
Optimizing muscle mass: therapeutic target to prevent experimental hepatic encephalopathy.

Optimizing muscle mass: therapeutic target to prevent experimental hepatic encephalopathy.

Chantal *Bémeur, Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Sarcopenia and Myosteatosis Increase the Risk of Hepatic Encephalopathy in Cirrhotic Patients.

Sarcopenia and Myosteatosis Increase the Risk of Hepatic Encephalopathy in Cirrhotic Patients.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Christopher F. Rose.

L-Ornithine Phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

L-Ornithine Phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

Rune Gangsøy Kristiansen, Christopher Rose, Ole Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased bbb permeability via NKCC1.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased bbb permeability via NKCC1.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Beneficial effects of muscle mass optimization using leucine supplementation and exercise training in the prevention of hepatic encephalopathy in experimental cirrhosis.

Beneficial effects of muscle mass optimization using leucine supplementation and exercise training in the prevention of hepatic encephalopathy in experimental cirrhosis.

Chantal *Bémeur, Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Oral
Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral
The novel glutaminase inhibitor CB-839 prevents oral glutamine-induced hyperammonemia in portacaval shunted rats.

The novel glutaminase inhibitor CB-839 prevents oral glutamine-induced hyperammonemia in portacaval shunted rats.

Cristina R. Bosoi, Marc-André Clément, Mélanie Tremblay, Christopher F. Rose.

Systemic oxidative stress induction leads to brain edema in hyperammonemic portacaval-shunted rats.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Beneficial effects of muscle mass optimization using leucine supplementation and exercise training in the prevention of hepatic encephalopathy in experimental cirrhosis.

Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Implication de l

Implication de l'hypotension dans la pathogenèse de l'encéphalopathie hépatique.

Marc-André Clément, Mélanie Tremblay, Christopher F. Rose.

Glutathione depletion leads to brain edema in portacaval-shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

L-Ornithine Phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

L-Ornithine Phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

Rune Gangsøy Kristiansen, Christopher F. Rose, Ole-Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø.

Impact of muscle mass optimization in the prevention of hepatic encephalopathy in experimental cirrhosis.

Impact of muscle mass optimization in the prevention of hepatic encephalopathy in experimental cirrhosis.

Chantal Bémeur, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Inhibiting lactate synthesis: a new therapeutic target for the treatment of hepatic encephalopathy.

Inhibiting lactate synthesis: a new therapeutic target for the treatment of hepatic encephalopathy.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Cristina R. Bosoi, Claudia Zwingmann, Helen Marin, Christian Parent-Robitaille, Jimmy Huynh, Mélanie Tremblay, Christopher F. Rose.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

Rune Gangsøy Kristiansen, Christopher F. Rose, Ole-Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø.

Oral
L

L'impact de l’isoleucine et de l’exercice physique sur l’état métabolique, la masse musculaire et l’encéphalopathie hépatique chez des rats cirrhotiques.

Cristina R. *Bosoi, Chantal Bémeur, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Impact of isoleucine and exercise on metabolic state, muscle mass and hepatic encephalopathy in cirrhotic rats.

Impact of isoleucine and exercise on metabolic state, muscle mass and hepatic encephalopathy in cirrhotic rats.

Chantal Bémeur, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral
Systemic oxidative stress induction aggravates hepatic encephalopathy in hyperammonemic portacaval-shunted rats.

Systemic oxidative stress induction aggravates hepatic encephalopathy in hyperammonemic portacaval-shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Oral
Chronic hyperammonemia “priming” alleviates the induction of oxidative stress and development of brain edema following an acute liver insult.

Chronic hyperammonemia “priming” alleviates the induction of oxidative stress and development of brain edema following an acute liver insult.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Oral

Le méthylglyoxal et l'encéphalopathie hépatique.

Vi T. Tran, Laurent Bilodeau, Cristina R. Bosoi, Mélanie Tremblay, Mireille Bélanger, Christopher F. Rose.

OpenAccess
Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Cristina R. Bosoi, Christopher F. Rose.

Astrocyte glutamine synthetase: pivotal in health and disease.

Astrocyte glutamine synthetase: pivotal in health and disease.

Christopher F. Rose, Alexei Verkhratsky, Vladimir Parpura.

L

L'encéphalopathie hépatique sévère est retardée chez des rats souffrant d’une décompensation hépatique aigue durant une hyperammoniémie chronique.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Le méthylglyoxal et l

Le méthylglyoxal et l'encéphalopathie hépatique.

Vi T. Tran, Laurent Bilodeau, Cristina R. Bosoi, Mélanie Tremblay, Mireille Bélanger, Christopher F. Rose.

Onset of severe hepatic encephalopathy is delayed in rats with acute liver insult superimposed on chronic hyperammonemia compared to rats with acute liver failure: a look at underlying mechanisms.

Onset of severe hepatic encephalopathy is delayed in rats with acute liver insult superimposed on chronic hyperammonemia compared to rats with acute liver failure: a look at underlying mechanisms.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Role of cerebral lactate in the pathogenesis of brain edema in cirrhotic rats.

Role of cerebral lactate in the pathogenesis of brain edema in cirrhotic rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

L

L'inhibition de la xanthine oxydase atténue l'oedème cérébral chez des rats avec insuffisance hépatique chronique.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Le rôle de l

Le rôle de l'encéphalopathie hépatique dans la susceptibilité accrue à l’insulte neuronale induite par hypotension/ hypoxie cérébrale.

Christian Parent-Robitaille, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral
Increased cerebral lactate contributes to brain edema in cirrhotic rats.

Increased cerebral lactate contributes to brain edema in cirrhotic rats.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral
Systemic oxidative stress induction leads to brain edema in hyperammonemic portacaval-shunted rats.

Systemic oxidative stress induction leads to brain edema in hyperammonemic portacaval-shunted rats.

Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral
Le rôle du stress oxydatif dans la pathogenèse de l’œdème cérébral dans l’encéphalopathie hépatique.

Le rôle du stress oxydatif dans la pathogenèse de l’œdème cérébral dans l’encéphalopathie hépatique.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Implication de la glutaminase dans l

Implication de la glutaminase dans l'insuffisance hépatique chronique.

Ada Rivera, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral
Role of oxidative stress in prevention of brain edema during an acute deterioration of chronic liver failure.

Role of oxidative stress in prevention of brain edema during an acute deterioration of chronic liver failure.

Cristina R. *Bosoi, Chantal Bémeur, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral
Glutathione depletion leads to brain edema in portacaval-shunted rats.

Glutathione depletion leads to brain edema in portacaval-shunted rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral
Xanthine oxidase inhibition attenuates brain edema in in rats with liver failure.

Xanthine oxidase inhibition attenuates brain edema in in rats with liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

Vikram Sharma, Gabriella A. M. Ten Have, Lars Ytrebø, Sambit Sen, Christopher F. Rose, R. Neil Dalton, Charles Turner, Arthur Revhaug, Hans M. H. van Eijk, Nicolaas E. P. Deutz, Rajiv Jalan, Rajeshwar P. Mookerjee, Nathan A. Davies.

OpenAccess
Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy.

Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy.

Christopher F. Rose.

OpenAccess
Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Jimmy Huynh, Christian Parent-Robitaille, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

Allopurinol attenuates systemic oxidative stress and hyperammonemia in bile-duct ligated rats.

Allopurinol attenuates systemic oxidative stress and hyperammonemia in bile-duct ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Evidence systemic oxidative stress represents a “first hit” in the multifactorial pathogenesis of brain edema in chronic liver failure.

Evidence systemic oxidative stress represents a “first hit” in the multifactorial pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Systemic oxidative stress followed by increases in ammonia and lactate is involved in the pathogenesis of brain edema in chronic liver failure.

Systemic oxidative stress followed by increases in ammonia and lactate is involved in the pathogenesis of brain edema in chronic liver failure.

Claudia Zwingmann, Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Oral
Impaired lactate metabolism, not brain ammonia and glutamine, contributes to the pathogenesis of brain edema in minimal hepatic encephalopathy.

Impaired lactate metabolism, not brain ammonia and glutamine, contributes to the pathogenesis of brain edema in minimal hepatic encephalopathy.

Christian Parent-Robitaille, Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Oral
Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Keith Anderson, Mélanie Tremblay, Christopher F. Rose.

L

L'augmentation de novo du lactate cérébral, indépendamment des niveaux d’ammoniaque et glutamine, est impliquée dans la pathogénèse de l’œdème cérébral dans l’insuffisance hépatique chronique.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Le cotransporteur Na-K-Cl est impliqué dans la pathogénèse de l’œdème cérébral chez les rats avec une ligature de la voie biliaire.

Le cotransporteur Na-K-Cl est impliqué dans la pathogénèse de l’œdème cérébral chez les rats avec une ligature de la voie biliaire.

Jimmy Huynh, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Increased de novo synthesis of brain lactate, independent of brain ammonia and glutamine, is implicated in the pathogenesis of brain edema in chronic liver failure.

Increased de novo synthesis of brain lactate, independent of brain ammonia and glutamine, is implicated in the pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Dose dependent effects of AST-120 (spherical carbon adsorbent) on arterial ammonia, brain edema, and systemic inflammatory marker (TNF-a) in bile duct ligated rats.

Dose dependent effects of AST-120 (spherical carbon adsorbent) on arterial ammonia, brain edema, and systemic inflammatory marker (TNF-a) in bile duct ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral
AST-120 (spherical carbon adsorbent) treatment prevents hyperammonemia and brain edema in cirrhotic rats.

AST-120 (spherical carbon adsorbent) treatment prevents hyperammonemia and brain edema in cirrhotic rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Neuropathological changes in the brain of pigs with acute liver failure.

Neuropathological changes in the brain of pigs with acute liver failure.

Rune Gangsøy Kristiansen, Sigurd Lindal, Kate Myreng, Arthur Revhaug, Lars Marius Ytrebø, Christopher F. Rose.

OpenAccess
Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Xiaoling Yang, Cristina R. Bosoi, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Increase brain lactate in hepatic encephalopathy: Cause or consequence?

Increase brain lactate in hepatic encephalopathy: Cause or consequence?

Christopher F. Rose.

L

L'œdème cérébral est associé avec le stress oxydatif systémique et non central dans les rats avec ligature de la voie biliaire.

Xiaoling Yang, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral
AST-120 (adsorbant sphérique de charbon) atténue l

AST-120 (adsorbant sphérique de charbon) atténue l'œdème cérébral et diminue le niveau artériel d'ammoniaque chez les rats avec ligature de voie biliaire.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation.

Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation.

Xiaoling Yang, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral
AST-120 (spherical carbon adsorbent) attenuates brain edema and lowers arterial ammonia in bile duct ligated rats.

AST-120 (spherical carbon adsorbent) attenuates brain edema and lowers arterial ammonia in bile duct ligated rats.

Christopher F. *Rose, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

AST-120 (spherical carbon adsorbent) lowers arterial ammonia and attenuates brain edema in bile-duct ligated rats.

Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. *Rose.

Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation.

Xiaoling Yang, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

The contributions of de novo arginine generation and arginase activity to whole body arginine metabolism in acute liver failure.

The contributions of de novo arginine generation and arginase activity to whole body arginine metabolism in acute liver failure.

Nathan Davies, Gabrie Ten Have, Vikram Sharma, Lars Ytrebø, Sambit Sen, Christopher Rose, Arthur Revhaug, R. P. Mookerjee, Rajiv Jalan, Nicholaas Deutz.

Oral
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L'effet synergique du stress oxydatif et l'hyperammonémie mène à l'œdème cérébral chez des rats avec une insuffisance hépatique chronique.

Cristina R. Bosoi, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral
Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Identifying the direct effects of ammonia on the brain.

Identifying the direct effects of ammonia on the brain.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.

L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.

Lars Marius Ytrebø, Rune Gangsøy Kristiansen, Hanne Maehre, Ole Martin Fuskevåg, Trine Kalstad, Arthur Revhaug, María Jover Cobos, Rajiv Jalan, Christopher F. Rose.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Hyperammonemia does not induce oxidative/nitrosative stress in rats with portacaval anastomosis.

Hyperammonemia does not induce oxidative/nitrosative stress in rats with portacaval anastomosis.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Infusion of isoleucine does not prevent encephalopathy or brain edema in rats with acute liver failure.

Infusion of isoleucine does not prevent encephalopathy or brain edema in rats with acute liver failure.

Javier Vaquero, Wenlei Jiang, Christopher F. Rose, Nicolas Chatauret, Roger F. Butterworth.

Infusion of isoleucine does not prevent encephalopathy or brain edema in rats with acute liver failure.

Javier Vaquero, Wenlei Jiang, Christopher F. Rose, Nicolas Chatauret, Roger F. Butterworth.

Ultrastructural changes of the brain in pigs with acute liver failure.

Lars M. Ytrebø, L. Sigurd, K. Myreng, Rune G. Kristiansen, Arthur Revhaug, Christopher F. Rose.

L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

Lars M. Ytrebø, Rune Gangsøy Kristiansen, Ole Martin Fuskevåg, Hanne Maehre, Arthur Revhaug, Rajiv Jalan, Christopher Rose.

L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

Lars M. Ytrebø, Rune Gangsøy Kristiansen, Ole Martin Fuskevåg, Hanne Maehre, Arthur Revhaug, Rajiv Jalan, Christopher Rose.

Ammonia removal triggers Ca2+ release from mitochondria in cultured astrocytes independent of cytoplasmic acidification.

Ammonia removal triggers Ca2+ release from mitochondria in cultured astrocytes independent of cytoplasmic acidification.

Christopher Rose, Helmut Kettenmann.

Oral
L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

Christopher *Rose, Lars M. Ytrebø, Rune Gangsøy Kristiansen, Ole Martin Fuskevåg, Hanne Maehre, Arthur Revhaug, Rajiv Jalan, Christopher Rose.

OpenAccess
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.

Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.

Christopher Rose, Lars M. Ytrebø, Nathan A. Davies, Sambit Sen, Geir I. Nedredal, Mireille Bélanger, Arthur Revhaug, Rajiv Jalan.

Effect of ammonia on astrocytic glutamate uptake/release mechanisms.

Effect of ammonia on astrocytic glutamate uptake/release mechanisms.

Christopher Rose.

OpenAccess
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.

Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.

Nicolas Chatauret, Paul Desjardins, Claudia Zwingmann, Christopher Rose, K. V. Rama Rao, Roger F. Butterworth.

OpenAccess
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

Sambit Sen, Christopher Rose, Lars M. Ytrebø, Nathan A. Davies, Geir I. Nedredal, Synnøve S. Drevland, Marianne Kjønnø, Frits W. Prinzen, Stephen J. Hodges, Nicolaas E. P. Deutz, Roger Williams, Roger F. Butterworth, Arthur Revhaug, Rajiv Jalan.

OpenAccess
Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.

Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.

Lars M. Ytrebø, Sambit Sen, Christopher Rose, Gabrie A. M. Ten Have, Nathan A. Davies, Stephen Hodges, Geir I. Nedredal, Manuel Romero-Gomez, Roger Williams, Arthur Revhaug, Rajiv Jalan, Nicolaas E. P. Deutz.

OpenAccess
Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.

Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.

Lars M. Ytrebø, Sambit Sen, Christopher Rose, Nathan A. Davies, Geir I. Nedredal, Ole-Martin Fuskevåg, Gabrie A. M. Ten Have, Frits W. Prinzen, Roger Williams, Nicolaas E. P. Deutz, Rajiv Jalan, Arthur Revhaug.

OpenAccess
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

Christopher Rose, Wolfgang Kresse, Helmut Kettenmann.

OpenAccess
Keeping cool in acute liver failure: rationale for the use of mild hypothermia.

Keeping cool in acute liver failure: rationale for the use of mild hypothermia.

Javier Vaquero, Christopher Rose, Roger F. Butterworth.

OpenAccess
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.

Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.

Christopher Rose, Vicente Felipo.

OpenAccess
Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

Mireille Bélanger, Paul Desjardins, Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

OpenAccess
Hypothermia in acute liver failure.

Hypothermia in acute liver failure.

Rajiv Jalan, Christopher Rose.

Albumin dialysis: a new therapeutic strategy for intoxication from protein-bound drugs.

Sambit Sen, Lars M. Ytrebø, Christopher Rose, Ole-Martin Fuskevåg, Nathan A. Davies, Geir I. Nedredal, Roger Williams, Arthur Revhaug, Rajiv Jalan.

OpenAccess
Contractile response of femoral arteries in pigs with acute liver failure.

Contractile response of femoral arteries in pigs with acute liver failure.

Lars M. Ytrebø, S. Ekse, Sambit Sen, Christopher Rose, Geir I. Nedredal, O.-M. Fuskevåg, Rajiv Jalan, Arthur Revhaug.

OpenAccess
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.

Claudia Zwingmann, Nicolas Chatauret, Christopher Rose, Dieter Leibfritz, Roger F. Butterworth.

OpenAccess
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

Nicolas Chatauret, Claudia Zwingmann, Christopher Rose, Dieter Leibfritz, Roger F. Butterworth.

OpenAccess

Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.

Paul Desjardins, Anny Sauvageau, Alain Bouthillier, Darren Navarro, Alan S. Hazell, Christopher Rose, Roger F. Butterworth.

OpenAccess
Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?

Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?

Christopher Rose.

OpenAccess
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

OpenAccess

Increased expression of 'peripheral-type' benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis.

Anny Sauvageau, Paul Desjardins, Violina Lozeva, Christopher Rose, Alan S. Hazell, Alain Bouthillier, Roger F. Butterworth.

OpenAccess
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

Nicolas Chatauret, Christopher Rose, Guy Therrien, Roger F. Butterworth.

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure.

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure.

Christopher Rose, Adrianna Michalak, Marc Pannunzio, Nicolas Chatauret, Andrea Rambaldi, Roger F. Butterworth.

L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.

L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.

Christopher Rose, Adrianna Michalak, K. V. Rama Rao, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

OpenAccess
Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

Christopher Rose, Roger F. Butterworth, Joseph Zayed, Louise Normandin, Kathryn Todd, Adrianna Michalak, Laurent Spahr, Pierre-Michel Huet, Gilles Pomier-Layrargues.

OpenAccess
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.

Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.

Paul Desjardins, K. V. Rao, Adrianna Michalak, Christopher Rose, Roger F. Butterworth.

OpenAccess
Role of manganese in the pathogenesis of portal-systemic encephalopathy.

Role of manganese in the pathogenesis of portal-systemic encephalopathy.

Gilles P. Layrargues, Christopher Rose, Laurent Spahr, Joseph Zayed, Louise Normandin, Roger F. Butterworth.

OpenAccess
L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

Christopher Rose, Adrianna Michalak, Pierre Pannunzio, Guy Therrien, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

OpenAccess
Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

K. Knecht, Adrianna Michalak, Christopher Rose, Jeffrey D. Rothstein, Roger F. Butterworth.

Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.

Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.

Guy Therrien, Christopher Rose, Joanne Butterworth, Roger F. Butterworth.

The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?

The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?

Jean-Pascal de Waele, Robert M. Audet, Christopher Rose, Roger F. Butterworth.

OpenAccess
Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, for US Acute Liver Failure Study Group.

The Nutrition in Cirrhosis Guide.

The Nutrition in Cirrhosis Guide.

Puneeta Tandon, Vanessa DenHeyer, Kathleen P Ismond, Jan Kowalczewski, Maitreyi Raman, Tannaz Eslamparast, Chantal Bémeur, Christopher Rose.

Therapeutic Hypothermia.

Therapeutic Hypothermia.

Rajiv Jalan, Christopher Rose.

Encephalopathy and Nitrogen Metabolism in Liver Failure

Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

OpenAccess

Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.

Adrianna Michalak, Christopher Rose, Roger F. Butterworth.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, Roger F. Butterworth, Joseph Zayed, Laurent Spahr, Pierre-Michel Huet, Gilles Pomier-Layrargues.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, K. V. Rama Rao, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.

Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.

Adrianna Michalak, Christopher Rose, Paul N. Buu, Roger F. Butterworth.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, Guy Therrien, Roger F. Butterworth.

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

Adrianna Michalak, Christopher Rose, Joanne Butterworth, Roger F. Butterworth.

Advances in Hepatic Encephalopathy and Metabolism in Nitrogen Exchange.

Guy Therrien, Christopher Rose, Roger F. Butterworth.

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