Hepato-neuro lab

Christopher F. Rose, Ph.D.

 
Christopher F. Rose

 Dr Rose is a full Professor at the Department of Medicine at the Université de Montréal and researcher at CRCHUM since 2006. He's also affiliated to pharmacology and nutrition departments.

 Full Professor, Departments of medicine, pharmacology and nutrition, Université de Montréal

 2006 - now

  Social media profiles :

Career

  • (2006-now): Research professor at Université de Montréal.
  • (2003-2006) Post-doctoral Fellow (Canadian Institutes of Health Research),
    Laboratory of Neurobiology, Valencia, Spain.
  • (2001-2003) Post-doctoral Fellow (Foundation Alexander von Humboldt),
    Max-Delbrück Center for Molecular Medicine, Cellular Neuroscience, Berlin, Germany.
  • (1994-2000) Ph.D.,
    Université de Montréal, under the supervision of Dr Roger Butterworth

Related Publications

The attenuation of hyperammonemia by genetically engineered E. coli Nissle counters memory deficits in an experimental model of cirrhosis and hepatic encephalopathy.

Rafael Ochoa-Sanchez, Alexis Monnet, Farzaneh Tamnanloo, Mariana M. Oliveira, Mélanie Tremblay, Mylene Perreault, Bill Querbes, Caroline Kurtz, Christopher F. Rose.

Genetically Engineered E. coli Nissle attenuates hyperammonemia and improves memory in an experimental model of cirrhosis and hepatic encephalopathy.

Rafael Ochoa-Sanchez, Alexis Monnet, Farzaneh Tamnanloo, Mariana M. Oliveira, Mélanie Tremblay, Mylene Perreault, Bill Querbes, Caroline B. Kurtz, Christopher F. Rose.

Obesity accelerates and exacerbates neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Oral

Uncovering sex-based differences in a rat model of chronic liver disease and hepatic encephalopathy

Mariana M. Oliveira, Alexis Monnet-Aimard, Mélanie Tremblay, Christopher F. Rose.

Developing a New Animal Model of Episodic Hepatic Encephalopathy.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Obesity-induced cirrhosis results in more complex and poor neurological performance related to hepatic encephalopathy in cirrhosis.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Glutamine synthetase in the blood-brain barrier: role in hindering hyperammonemia-induced neurotoxicity?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Characterization of a novel animal model of episodic hepatic encephalopathy.

Farzaneh Tamnanloo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.

The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.

Mathilde Mouchiroud, Étienne Camiré, Manal Aldow, Alexandre Caron, Éric Jubinville, Laurie Turcotte, Inès Kaci, Marie-Josée Beaulieu, Christian Roy, Sébastien M. Labbé, Thibault V. Varin, Yves Gélinas, Jennifer Lamothe, Jocelyn Trottier, Patricia L. Mitchell, Frédéric Guénard, William T. Festuccia, Philippe Joubert, Christopher F. Rose, Constantine J. Karvellas, Olivier Barbier, Mathieu C. Morissette, André Marette, Mathieu Laplante.

Sarcopenia in the context of liver transplantation: What is the prognosis?

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher Rose, Chantal Bémeur.

Characterization of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Uncovering the protective mechanism of the BBB against ammonia neurotoxicity.

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Malnutrition in chronic liver disease: Implications for quality of life and hepatic encephalopathy

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher Rose, Chantal Bémeur.

Association entre la sarcopénie et le pronostic des patients cirrhotiques dans le contexte de la transplantation hépatique.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Évaluation d’un guide éducatif en nutrition destiné aux gens atteints de maladie hépatique chronique.

Manila Sophasath, Mélanie Tremblay, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Oral

The association between liver type fatty acid binding protein (FABP1) serum levels and clinical outcomes in patients with non-acetaminophen acute liver failure: a cohort study.

Constantine Karvellas, Jaime Speiser, William M. Lee, Mélanie Tremblay, Christopher F. Rose.

Sarcopenia is associated with a worst prognosis in cirrhotic patients in the context of liver transplantation.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Progressive resistance training prevents loss of muscle mass and strength in bile duct ligated rats.

Progressive resistance training prevents loss of muscle mass and strength in bile duct ligated rats.

Luise Aamann, Rafael Ochoa-Sanchez, Mariana Oliveira, Mélanie Tremblay, Chantal Bémeur, Gitte Dam, Hendrik Vilstrup, Niels Kristian Aagaard, Christopher Rose.

The association between sarcopenia and the prognosis of cirrhotic patients in liver transplantation.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Association entre la sarcopénie et le pronostic des patients cirrhotiques dans le contexte de la transplantation hépatique.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Genetically Engineered E. coli nissle Attenuates Hyperammonemia in Two Experimental Models of Hepatic Encephalopathy.

Rafael Ochoa-Sanchez, Mariana M. Oliveira, Grégory Petrazzo, Yossi Dagon, Kip West, Lauren Renaud, Caroline Kurtz, Christopher F. Rose.

Evaluate the efficiency of Rifaximin treatment in a bile-duct ligated model of cirrhosis.

Gregory. Petrazzo, Mariana M. Oliveira, Rafael. Ochoa-Sanchez, Mélanie. Tremblay, Christopher F. Rose.

Impact of gender on development of chronic liver disease and hepatic encephalopathy following bile duct ligation.

Mariana Oliveira, Mélanie Tremblay, Christopher Rose.

Genetically Engineered E. coli nissle Attenuates Hyperammonemia in Two Experimental Models of Hepatic Encephalopathy.

Rafael Ochoa-Sanchez, Mariana Oliveira, Grégory Petrazzo, Yossi Dagon, Kip West, Lauren Renaud, Caroline Kurtz, Christopher F. Rose.

Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.

Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.

Rafael Ochoa-Sanchez, Christopher F. Rose.

Nutritional status in patients with chronic liver disease: Impact on hepatic encephalopathy and health-related quality of life.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis.

Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis.

Rahima A. Bhanji, Carlos Moctezuma-Velazquez, Andres Duarte-Rojo, Maryam Ebadi, Sunita Ghosh, Christopher Rose, Aldo J. Montano-Loza.

Diagnosis and Management of Hepatic Encephalopathy: A Case-based Guide

Diagnosis and Management of Hepatic Encephalopathy: A Case-based Guide

Julien Bissonnette, Christopher F. Rose.

Alcohol accelerates hepatic encephalopathy in a rat bile duct ligation model.

Xiaoru Chen, Mariana Oliveira, Grégory Petrazzo, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher Rose.

Impact de la sarcopénie lors de la transplantation hépatique : une étude rétrospective en cours.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

OpenAccess
Assessment of the spectrum of hepatic encephalopathy: A multicenter study.

Assessment of the spectrum of hepatic encephalopathy: A multicenter study.

Bradley Reuter, Kara Walter, Julien Bissonnette, Michael D. Leise, Jennifer Lai, Puneeta Tandon, Patrick S. Kamath, Scott W. Biggins, Christopher F. Rose, James B. Wade, Jasmohan S. Bajaj.

Impact de la sarcopénie lors de la transplantation hépatique : une étude rétrospective en cours.

Mimosa Nguyen, Mélanie Tremblay, Geneviève Huard, An Tang, Christopher F. Rose, Chantal Bémeur.

Impact de l'état nutritionnel sur la qualité de vie et l'encéphalopathie hépatique lors de maladies chroniques du foie.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Oral

Glutamine synthetase in the blood-brain barrier: targeting endothelial cells for the treatment of hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Nutritional status, hepatic encephalopathy and health-related quality of life in patients with chronic liver disease.

Christopher F. *Rose, Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Obesity exacerbates the neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Christopher F. *Rose, Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Christopher F. Rose.

Nouveau modèle d’encéphalopathie hépatique épisodique due à la cirrhose.

Kim Phat Pham, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Caractérisation de la microglie dans un modèle expérimental du syndrome de leigh version canadienne française.

Raluca Ticala, Mélanie Tremblay, Christopher F. Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

José I. Fortea, Alexander Zipprich, Carolina Fernandez-Mena, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Juan Bañares, Belén Rodríguez-Sánchez, Emilia Cercenado, Marc-André Clément, Christopher F. Rose, Rafael Bañares, Javier Vaquero, Cristina Ripoll.

Nutritional status, hepatic encephalopathy and health-related quality of life in patients with chronic liver disease.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Can We Accurately Assess the Spectrum of Hepatic Encephalopathy (HE) Stages? A Multi-Center Initiative using Standardized Simulated Patients.

Jasmohan S. Bajaj, Bradley Reuter, Kara Walter, Scott W. Biggins, Julien Bissonnette, Christopher F. Rose, Jennifer C. Lai, Michael D. Leise, Patrick S. Kamath, Puneeta Tandon, James Wade.

Obesity exacerbates the neurological impairments associated to hepatic encephalopathy in chronic liver disease.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Glutamine synthetase in endothelial cells of the blood-brain barrier: role in protecting the brain from hyperammonemia-induced neurotoxicity?

Mariana Macedo de Oliveira, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.

The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, U. S. Acute Liver Failure Study Group.

Oral

Liposome-supported peritoneal dialysis for the treatment of hyperammonemia-associated encephalopathy.

Valentina Agostoni, G. Giacalone, Cristina R. Bosoi, Christopher F. Rose, Jean-Christophe Leroux.

Glutamine synthetase in endothelial cells of the blood-brain barrier: role in preventing protecting the brain in hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Oral

Characterization of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Christopher F. Rose.

Oral

Hepatic encephalopathy and health-related quality of life among cirrhotic patients: Scope of nutritional status.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher Rose, Chantal Bémeur.

Glutamine synthetase in endothelial cells of the blood-brain barrier: new target for the treatment of hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher Rose.

Nouveau modèle d’encéphalopathie hépartique épisodique due à la cirrhose.

Kim Phat Pham, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Impact de l’état nutritionnel sur l’encéphalopathie hépatique et la qualité de vie chez les patients atteints de maladie chronique du foie : Résultats préliminaires d’une étude prospective.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Comparaison d’outils d’évaluation nutritionnelle lors de cirrhose.

Annie Lamoussenerie, Cassandra Picinbono-Larose, Mélanie Tremblay, Thierry Cresson, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Oral

Impact de l'état nutritionnel sur l'encéphalopathie hépatique et la qualité de vie chez les patients atteints de maladie chronique du foie: résultats préliminaires d'une étude prospective.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Vincent, Geneviève Huard, Christopher Rose, Chantal Bémeur.

New animal model of obesity and chronic liver disease to provide insights on non-alcoholic liver disease-induced hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Marcos Ocana-Sanchez, Christopher F. Rose.

Glutamine synthetase in endothelial cells of the blood-brain barrier: less but not insignificant?

Christopher F. *Rose, Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

Cristina R. Bosoi, Mariana M. Oliveira, Rafael Ochoa-Sanchez, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose, Chantal Bémeur.

Ammonia toxicity: from head to toe?

Ammonia toxicity: from head to toe?

Srinivasan Dasarathy, Rajeshwar P. Mookerjee, Veronika Rackayova, Vinita Rangroo Thrane, Balasubramaniyan Vairappan, Peter Ott, Christopher F. Rose.

In reply: Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

U. S. Acute Liver Failure Study Group, Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, U. S. Acute Liver Failure Study Group.

Oral

Effects of anaerobic exercise in muscle mass optimization in bile duct ligated rats.

Luise Aamann, Rafael Ochoa-Sanchez, Mariana M. Oliveira, Mélanie Tremblay, Chantal Bémeur, Gitte Dam, Hendrik Vilstrup, Niels Kristian Aagaard, Christopher F. Rose.

Oral

Skeletal muscle abnormalities increase the risk of overt hepatic encephalopathy and hyperammonemia in patients with cirrhosis.

Rahima A. Bhanji, Andres Duarte-Rojo, Christopher Rose, Aldo J. Montano-Loza.

Oral

Oral Ornithine Phenylacetate Attenuates Muscle Mass Loss and Prevents Hepatic Encephalopathy in BDL Rats.

Marc-André Clément, Cristina R. Bosoi, Mariana Oliveira, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose.

Elevated Liver Fatty Acid Binding Protein (FABP1) Serum Levels Improve Prognostic Discrimination of King’s College Criteria and the ALSFG Index in Acetaminophen-induced Acute Liver Failure: A Nested Case Control Study.

Constantine Jason Karvellas, Jaime Lynn Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose.

Brain-type Fatty Acid Binding Protein (FABP7) and Neurological Complications of Acetaminophen-induced Acute Liver Failure.

Constantine Jason Karvellas, Jaime Lynn Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose.

Nutritional status assessment in patients with chronic liver disease: a pilot study.

Annie Lamoussenerie, Cassandra Picinbono-Larose, Mélanie Tremblay, Catherine Demers, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Development of a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Marc-André Clément, Marcos Ocana-Sanchez, Christopher F. Rose.

Oral

Glutamine synthetase in endothelial cells of the blood-brain barrier: less but not insignificant ?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Impact of nutritional status on hepatic encephalopathy and quality of life in patients with chronic liver disease: preliminary results of a prospective study.

Cassandra Picinbono-Larose, Annie Lamoussenerie, Mélanie Tremblay, Catherine Demers, Catherine Vincent, Geneviève Huard, Christopher F. Rose, Chantal Bémeur.

Glutamine synthetase in endothelial cells of the blood-brain barrier: new target for the treatment of hepatic encephalopathy?

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Oral

Liver type fatty acid binding protein (FABP1) levels improve performance of prognostic models in acetaminophen induced acute liver failure.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Elaine M. Leslie, Christopher F. Rose.

Oral

Nouveau modèle d’encéphalopathie hépatique épisodique due à la cirrhose.

Kim Phat Pham, Rafael Ochoa-Sanchez, Mélanie Tremblay, Christopher F. Rose.

Brain-FABP serum levels and clinical outcomes in acetaminophen-induced acute liver failure.

Constantine Karvellas, Jaime Speiser, Mélanie Tremblay, William Lee, Christopher Rose.

Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, for US Acute Liver Failure Study Group.

The Nutrition in Cirrhosis Guide.

The Nutrition in Cirrhosis Guide.

Puneeta Tandon, Vanessa DenHeyer, Kathleen P Ismond, Jan Kowalczewski, Maitreyi Raman, Tannaz Eslamparast, Chantal Bémeur, Christopher Rose.

Oral

Elevated Liver Fatty Acid Binding protein serum levels improve prognostic discrimination of King’s College Criteria and the ALFSG index in acetaminophen-induced acute liver failure: a case control study.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Elaine M. Leslie, Christopher F. Rose.

The association between Brain Fatty Acid Binding protein serum levels with survival and intracranial hypertension in acetaminophen-induced acute liver failure patients: a case control study.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Gurnit Kaur, Elaine M. Leslie, Christopher Rose, US Acute Liver Failure Study Group.

Évaluation de l'état nutritionnel lors de cirrhose.

Annie Lamoussenerie, Mélanie Tremblay, Thierry Cresson, An Tang, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Developing a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Mariana Oliveira, Cristina Bosoi, Marc-André Clément, Christopher F. Rose.

Evaluation of nutritional status in patients with chronic liver disease: a pilot study.

Annie Lamoussenerie, Mélanie Tremblay, Thierry Cresson, An Tang, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

The role of the blood-brain barrier in ammonia homeostasis: targeting endothelial cells for the treatment of hepatic encephalopathy.

Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose.

Oral

Beneficial effects of ornithine phenylacetate to attenuate muscle mass loss and to prevent hepatic encephalopathy in experimental cirrhosis.

Christopher F. *Rose, Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose.

Évaluation de l'état nutritionnel lors de cirrhose.

Annie Lamoussenerie, Mélanie Tremblay, Thierry Cresson, An Tang, Catherine Vincent, Christopher F. Rose, Chantal Bémeur.

Oral

Cirrhotic patients with sarcopenia and sarcopenic obesity have an increased risk of hyperammonemia and hepatic encephalopathy.

Aldo Montano-Loza, Andres Duarte-Rojo, Rahima Bhanji, Christopher F. Rose.

Oral

Ornithine phenylacetate attenuates loss of muscle mass and improves hepatic encephalopathy in bile-duct ligated rats.

Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabrie Ten Have, Nicholaas Deutz, Christopher F. Rose.

Oral

Minimal hepatic encephalopathy renders the brain susceptible to hypotension-induced neuronal cell loss in BDL rats.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Estudio del efecto de la enoxaparina sobre la cirrosis e hipertensión portal experimental.

Jose Ignacio Fortea, Alexander Zipprich, Carolina Mena Fernandez, Christopher F. Rose, Juan Bañares, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Marc-André Clément, Javier Vaquero, Rafael Bañares, Cristina Ripoll.

Oral

Leucine et exercices : bénéfique lors d'encéphalopathie expérimentale.

Corine Fontaine, Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Oral

Neuroinflammation et activation microgliale chez des rats cirrhotiques soumis à une hypotension.

Maxime Hovington, Marc-André Clément, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Arthur J. L. Cooper, Chantal Bémeur, Cristina Cudalbu, Gitte Dam, Alexander S. Thrane, Arthur J. L. Cooper, Christopher F. Rose.

Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.

Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.

Rune Gangsøy Kristiansen, Christopher F. Rose, Lars Marius Ytrebø.

Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure.

Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure.

Geir I. Nedredal, Kjetil Elvevold, Marcio F. Chedid, Lars M. Ytrebø, Christopher F. Rose, Sambit Sen, Bård Smedsrød, Rajiv Jalan, Arthur Revhaug.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Valentina Agostoni, Soo Hyeon Lee, Vincent Forster, Meriam Kabbaj, Cristina Bosoi, Mélanie Tremblay, Matthias Zadory, Christopher F. Rose, Jean-Christophe Leroux.

Long term oral treatment of ornithine phenylacetate increases lean mass and attenuates brain edema in bile-duct ligated rats.

Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabrie Ten Have, Nicolaas E. P. Deutz, Christopher F. Rose.

Oral

Minimal hepatic encephalopathy leads to hypotension-induced neuronal cell loss in BDL rats.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Enoxaparin treatment does not ameliorate liver fibrosis or portal hypertension in experimental models of cirrhosis in rats.

Jose Ignacio Fortea, Alexander Zipprich, Carolina-Mena Fernandez, Christopher F. Rose, Juan Bañares, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Marc-André Clément, Javier Vaquero, Rafael Bañares, Cristina Ripoll.

Sarcopenia and Sarcopenic-Obesity are Associated with Hyperammonemia and Increased Risk of Hepatic Encephalopathy in Cirrhotics.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Rahima A. Bhanji, Christopher F. Rose.

Cirrhotic patients with sarcopenia and sarcopenic-obesity have an increased risk of hyperammonemia and hepatic encephalopathy.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Rahima A. Bhanji, Christopher F. Rose.

Liposome-Supported Peritoneal Dialysis in the Treatment of Severe Hyperammonemia.

Valentina Agostoni, Vincent Forster, Cristina Bosoi, Mélanie Tremblay, Christopher Rose, Jean-Christophe Leroux.

Impact d'un stress inflammatoire et nutritionnel dans un modèle cellulaire d'acidose lactique.

Rafaela Almeida, Mélanie Tremblay, Christopher Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Impact d’un stress de type inflammatoire et nutritionnel dans un modèle cellulaire d’acidose lactique.

Rafaela Almeida, Mélanie Tremblay, Christopher Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Impact d'un stress inflammatoire et nutritionnel dans un modèle cellulaire d'acidose lactique.

Rafaela Almeida, Mélanie Tremblay, Christopher Rose, Consortium de l'acidose lactique, Chantal Bémeur.

Oral

Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Bile-ligated rats are susceptible to hypotension-induced neuronal cell loss: implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Muscle mass optimization prevents experimental hepatic encephalopathy.

Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Sarcopenia and Myosteatosis Increase the Risk of Hepatic Encephalopathy in Cirrhotic Patients.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Christopher F. Rose.

Effet du stress oxydatif et de l'ammoniaque sur la perméabilité de la barrière hémato-encéphalique dans la maladie de foie chronique.

Valérie Boucher, Mélanie Tremblay, Christopher F. Rose.

Reply to: "Pivotal preclinical trial of the spheroid reservoir bioartificial liver".

Reply to: "Pivotal preclinical trial of the spheroid reservoir bioartificial liver".

Jaime M. Glorioso, Shennen A. Mao, Brian Rodysill, Taufic Mounajjed, Walter K. Kremers, Faysal Elgilani, Raymond D. Hickey, Hakon Haugaa, Christopher F. Rose, Bruce Amiot, Scott L. Nyberg.

Pivotal preclinical trial of the spheroid reservoir bioartificial liver.

Pivotal preclinical trial of the spheroid reservoir bioartificial liver.

Jaime M. Glorioso, Shennen A. Mao, Brian Rodysill, Taufic Mounajjed, Walter K. Kremers, Faysal Elgilani, Raymond D. Hickey, Hakon Haugaa, Christopher F. Rose, Bruce Amiot, Scott L. Nyberg.

Caractérisation d'un modèle cellulaire de stress de type inflammatoire et nutritionnel lors du syndrome de leigh version canadienne française.

Rafaela Almeida, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur, Consortium de l'acidose lactique.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Optimizing muscle mass: therapeutic target to prevent experimental hepatic encephalopathy.

Chantal *Bémeur, Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased BBB permeability via NKCC1.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Sarcopenia and Myosteatosis Increase the Risk of Hepatic Encephalopathy in Cirrhotic Patients.

Aldo J. Montano-Loza, Andres Duarte-Rojo, Christopher F. Rose.

Oral

The novel glutaminase inhibitor CB-839 prevents oral glutamine-induced hyperammonemia in portacaval shunted rats.

Cristina R. Bosoi, Marc-André Clément, Mélanie Tremblay, Christopher F. Rose.

Oral

Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Beneficial effects of muscle mass optimization using leucine supplementation and exercise training in the prevention of hepatic encephalopathy in experimental cirrhosis.

Chantal *Bémeur, Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased bbb permeability via NKCC1.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

L-Ornithine Phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

Rune Gangsøy Kristiansen, Christopher Rose, Ole Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø.

Systemic oxidative stress induction leads to brain edema in hyperammonemic portacaval-shunted rats.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Implication de l'hypotension dans la pathogenèse de l'encéphalopathie hépatique.

Marc-André Clément, Mélanie Tremblay, Christopher F. Rose.

Glutathione depletion leads to brain edema in portacaval-shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Beneficial effects of muscle mass optimization using leucine supplementation and exercise training in the prevention of hepatic encephalopathy in experimental cirrhosis.

Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

L-Ornithine Phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

Rune Gangsøy Kristiansen, Christopher F. Rose, Ole-Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø.

Impact of muscle mass optimization in the prevention of hepatic encephalopathy in experimental cirrhosis.

Chantal Bémeur, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Inhibiting lactate synthesis: a new therapeutic target for the treatment of hepatic encephalopathy.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Cristina R. Bosoi, Claudia Zwingmann, Helen Marin, Christian Parent-Robitaille, Jimmy Huynh, Mélanie Tremblay, Christopher F. Rose.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

Rune Gangsøy Kristiansen, Christopher F. Rose, Ole-Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø.

Oral

L'impact de l’isoleucine et de l’exercice physique sur l’état métabolique, la masse musculaire et l’encéphalopathie hépatique chez des rats cirrhotiques.

Cristina R. *Bosoi, Chantal Bémeur, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Impact of isoleucine and exercise on metabolic state, muscle mass and hepatic encephalopathy in cirrhotic rats.

Chantal Bémeur, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Systemic oxidative stress induction aggravates hepatic encephalopathy in hyperammonemic portacaval-shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Chronic hyperammonemia “priming” alleviates the induction of oxidative stress and development of brain edema following an acute liver insult.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Oral

Le méthylglyoxal et l'encéphalopathie hépatique.

Vi T. Tran, Laurent Bilodeau, Cristina R. Bosoi, Mélanie Tremblay, Mireille Bélanger, Christopher F. Rose.

OpenAccess
Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Cristina R. Bosoi, Christopher F. Rose.

Astrocyte glutamine synthetase: pivotal in health and disease.

Astrocyte glutamine synthetase: pivotal in health and disease.

Christopher F. Rose, Alexei Verkhratsky, Vladimir Parpura.

L'encéphalopathie hépatique sévère est retardée chez des rats souffrant d’une décompensation hépatique aigue durant une hyperammoniémie chronique.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Le méthylglyoxal et l'encéphalopathie hépatique.

Vi T. Tran, Laurent Bilodeau, Cristina R. Bosoi, Mélanie Tremblay, Mireille Bélanger, Christopher F. Rose.

Role of cerebral lactate in the pathogenesis of brain edema in cirrhotic rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Onset of severe hepatic encephalopathy is delayed in rats with acute liver insult superimposed on chronic hyperammonemia compared to rats with acute liver failure: a look at underlying mechanisms.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Le rôle de l'encéphalopathie hépatique dans la susceptibilité accrue à l’insulte neuronale induite par hypotension/ hypoxie cérébrale.

Christian Parent-Robitaille, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Role of oxidative stress in prevention of brain edema during an acute deterioration of chronic liver failure.

Cristina R. *Bosoi, Chantal Bémeur, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Implication de la glutaminase dans l'insuffisance hépatique chronique.

Ada Rivera, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Le rôle du stress oxydatif dans la pathogenèse de l’œdème cérébral dans l’encéphalopathie hépatique.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Systemic oxidative stress induction leads to brain edema in hyperammonemic portacaval-shunted rats.

Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Increased cerebral lactate contributes to brain edema in cirrhotic rats.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

L'inhibition de la xanthine oxydase atténue l'oedème cérébral chez des rats avec insuffisance hépatique chronique.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Glutathione depletion leads to brain edema in portacaval-shunted rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Xanthine oxidase inhibition attenuates brain edema in in rats with liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Jimmy Huynh, Christian Parent-Robitaille, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy.

Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy.

Christopher F. Rose.

Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

Vikram Sharma, Gabriella A. M. Ten Have, Lars Ytrebø, Sambit Sen, Christopher F. Rose, R. Neil Dalton, Charles Turner, Arthur Revhaug, Hans M. H. van Eijk, Nicolaas E. P. Deutz, Rajiv Jalan, Rajeshwar P. Mookerjee, Nathan A. Davies.

Allopurinol attenuates systemic oxidative stress and hyperammonemia in bile-duct ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Evidence systemic oxidative stress represents a “first hit” in the multifactorial pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Impaired lactate metabolism, not brain ammonia and glutamine, contributes to the pathogenesis of brain edema in minimal hepatic encephalopathy.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Systemic oxidative stress followed by increases in ammonia and lactate is involved in the pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Keith Anderson, Mélanie Tremblay, Christopher F. Rose.

L'augmentation de novo du lactate cérébral, indépendamment des niveaux d’ammoniaque et glutamine, est impliquée dans la pathogénèse de l’œdème cérébral dans l’insuffisance hépatique chronique.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Le cotransporteur Na-K-Cl est impliqué dans la pathogénèse de l’œdème cérébral chez les rats avec une ligature de la voie biliaire.

Jimmy Huynh, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Increased de novo synthesis of brain lactate, independent of brain ammonia and glutamine, is implicated in the pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Dose dependent effects of AST-120 (spherical carbon adsorbent) on arterial ammonia, brain edema, and systemic inflammatory marker (TNF-a) in bile duct ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

AST-120 (spherical carbon adsorbent) treatment prevents hyperammonemia and brain edema in cirrhotic rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Neuropathological changes in the brain of pigs with acute liver failure.

Neuropathological changes in the brain of pigs with acute liver failure.

Rune Gangsøy Kristiansen, Sigurd Lindal, Kate Myreng, Arthur Revhaug, Lars Marius Ytrebø, Christopher F. Rose.

OpenAccess
Increase brain lactate in hepatic encephalopathy: Cause or consequence?

Increase brain lactate in hepatic encephalopathy: Cause or consequence?

Christopher F. Rose.

OpenAccess
Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Xiaoling Yang, Cristina R. Bosoi, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

Oral

AST-120 (adsorbant sphérique de charbon) atténue l'œdème cérébral et diminue le niveau artériel d'ammoniaque chez les rats avec ligature de voie biliaire.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

L'œdème cérébral est associé avec le stress oxydatif systémique et non central dans les rats avec ligature de la voie biliaire.

Xiaoling Yang, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

AST-120 (spherical carbon adsorbent) attenuates brain edema and lowers arterial ammonia in bile duct ligated rats.

Christopher F. *Rose, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation.

Xiaoling Yang, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

AST-120 (spherical carbon adsorbent) lowers arterial ammonia and attenuates brain edema in bile-duct ligated rats.

Christopher F. *Rose, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation.

Xiaoling Yang, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

The contributions of de novo arginine generation and arginase activity to whole body arginine metabolism in acute liver failure.

Nathan Davies, Gabrie Ten Have, Vikram Sharma, Lars Ytrebø, Sambit Sen, Christopher Rose, Arthur Revhaug, R. P. Mookerjee, Rajiv Jalan, Nicholaas Deutz.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

L'effet synergique du stress oxydatif et l'hyperammonémie mène à l'œdème cérébral chez des rats avec une insuffisance hépatique chronique.

Cristina R. Bosoi, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Identifying the direct effects of ammonia on the brain.

Identifying the direct effects of ammonia on the brain.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.

L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.

Lars Marius Ytrebø, Rune Gangsøy Kristiansen, Hanne Maehre, Ole Martin Fuskevåg, Trine Kalstad, Arthur Revhaug, María Jover Cobos, Rajiv Jalan, Christopher F. Rose.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Hyperammonemia does not induce oxidative/nitrosative stress in rats with portacaval anastomosis.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Infusion of isoleucine does not prevent encephalopathy or brain edema in rats with acute liver failure.

Javier Vaquero, Wenlei Jiang, Christopher F. Rose, Nicolas Chatauret, Roger F. Butterworth.

Infusion of isoleucine does not prevent encephalopathy or brain edema in rats with acute liver failure.

Javier Vaquero, Wenlei Jiang, Christopher F. Rose, Nicolas Chatauret, Roger F. Butterworth.

Ultrastructural changes of the brain in pigs with acute liver failure.

Lars M. Ytrebø, L. Sigurd, K. Myreng, Rune G. Kristiansen, Arthur Revhaug, Christopher F. Rose.

L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

Lars M. Ytrebø, Rune Gangsøy Kristiansen, Ole Martin Fuskevåg, Hanne Maehre, Arthur Revhaug, Rajiv Jalan, Christopher Rose.

L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

Lars M. Ytrebø, Rune Gangsøy Kristiansen, Ole Martin Fuskevåg, Hanne Maehre, Arthur Revhaug, Rajiv Jalan, Christopher Rose.

Ammonia removal triggers Ca2+ release from mitochondria in cultured astrocytes independent of cytoplasmic acidification.

Christopher Rose, Helmut Kettenmann.

Oral

L-ornithine phenylacetate attenuates increase in arterial ammonia and intracranial pressure in a devascularised pig model of acute liver failure: A novel ammonia-lowering strategy for hepatic encephalopathy.

Christopher *Rose, Lars M. Ytrebø, Rune Gangsøy Kristiansen, Ole Martin Fuskevåg, Hanne Maehre, Arthur Revhaug, Rajiv Jalan, Christopher Rose.

OpenAccess
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.

Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.

Christopher Rose, Lars M. Ytrebø, Nathan A. Davies, Sambit Sen, Geir I. Nedredal, Mireille Bélanger, Arthur Revhaug, Rajiv Jalan.

OpenAccess
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.

Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.

Nicolas Chatauret, Paul Desjardins, Claudia Zwingmann, Christopher Rose, K. V. Rama Rao, Roger F. Butterworth.

Effect of ammonia on astrocytic glutamate uptake/release mechanisms.

Effect of ammonia on astrocytic glutamate uptake/release mechanisms.

Christopher Rose.

OpenAccess
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

Sambit Sen, Christopher Rose, Lars M. Ytrebø, Nathan A. Davies, Geir I. Nedredal, Synnøve S. Drevland, Marianne Kjønnø, Frits W. Prinzen, Stephen J. Hodges, Nicolaas E. P. Deutz, Roger Williams, Roger F. Butterworth, Arthur Revhaug, Rajiv Jalan.

OpenAccess
Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.

Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.

Lars M. Ytrebø, Sambit Sen, Christopher Rose, Gabrie A. M. Ten Have, Nathan A. Davies, Stephen Hodges, Geir I. Nedredal, Manuel Romero-Gomez, Roger Williams, Arthur Revhaug, Rajiv Jalan, Nicolaas E. P. Deutz.

OpenAccess
Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.

Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.

Lars M. Ytrebø, Sambit Sen, Christopher Rose, Nathan A. Davies, Geir I. Nedredal, Ole-Martin Fuskevåg, Gabrie A. M. Ten Have, Frits W. Prinzen, Roger Williams, Nicolaas E. P. Deutz, Rajiv Jalan, Arthur Revhaug.

OpenAccess
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.

Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.

Christopher Rose, Vicente Felipo.

OpenAccess
Keeping cool in acute liver failure: rationale for the use of mild hypothermia.

Keeping cool in acute liver failure: rationale for the use of mild hypothermia.

Javier Vaquero, Christopher Rose, Roger F. Butterworth.

OpenAccess
Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

Mireille Bélanger, Paul Desjardins, Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

Therapeutic Hypothermia.

Therapeutic Hypothermia.

Rajiv Jalan, Christopher Rose.

OpenAccess
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

Christopher Rose, Wolfgang Kresse, Helmut Kettenmann.

OpenAccess
Hypothermia in acute liver failure.

Hypothermia in acute liver failure.

Rajiv Jalan, Christopher Rose.

Albumin dialysis: a new therapeutic strategy for intoxication from protein-bound drugs.

Sambit Sen, Lars M. Ytrebø, Christopher Rose, Ole-Martin Fuskevåg, Nathan A. Davies, Geir I. Nedredal, Roger Williams, Arthur Revhaug, Rajiv Jalan.

OpenAccess
Contractile response of femoral arteries in pigs with acute liver failure.

Contractile response of femoral arteries in pigs with acute liver failure.

Lars M. Ytrebø, S. Ekse, Sambit Sen, Christopher Rose, Geir I. Nedredal, O.-M. Fuskevåg, Rajiv Jalan, Arthur Revhaug.

OpenAccess
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.

Claudia Zwingmann, Nicolas Chatauret, Christopher Rose, Dieter Leibfritz, Roger F. Butterworth.

Encephalopathy and Nitrogen Metabolism in Liver Failure

Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

OpenAccess
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

Nicolas Chatauret, Claudia Zwingmann, Christopher Rose, Dieter Leibfritz, Roger F. Butterworth.

OpenAccess

Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.

Paul Desjardins, Anny Sauvageau, Alain Bouthillier, Darren Navarro, Alan S. Hazell, Christopher Rose, Roger F. Butterworth.

OpenAccess
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

OpenAccess
Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?

Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?

Christopher Rose.

OpenAccess

Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis.

Anny Sauvageau, Paul Desjardins, Violina Lozeva, Christopher Rose, Alan S. Hazell, Alain Bouthillier, Roger F. Butterworth.

OpenAccess
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

Nicolas Chatauret, Christopher Rose, Guy Therrien, Roger F. Butterworth.

OpenAccess

Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.

Adrianna Michalak, Christopher Rose, Roger F. Butterworth.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, Roger F. Butterworth, Joseph Zayed, Laurent Spahr, Pierre-Michel Huet, Gilles Pomier-Layrargues.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, K. V. Rama Rao, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure.

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure.

Christopher Rose, Adrianna Michalak, Marc Pannunzio, Nicolas Chatauret, Andrea Rambaldi, Roger F. Butterworth.

OpenAccess
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.

Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.

Paul Desjardins, K. V. Rao, Adrianna Michalak, Christopher Rose, Roger F. Butterworth.

OpenAccess
Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

Christopher Rose, Roger F. Butterworth, Joseph Zayed, Louise Normandin, Kathryn Todd, Adrianna Michalak, Laurent Spahr, Pierre-Michel Huet, Gilles Pomier-Layrargues.

L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.

L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.

Christopher Rose, Adrianna Michalak, K. V. Rama Rao, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

OpenAccess
Role of manganese in the pathogenesis of portal-systemic encephalopathy.

Role of manganese in the pathogenesis of portal-systemic encephalopathy.

Gilles P. Layrargues, Christopher Rose, Laurent Spahr, Joseph Zayed, Louise Normandin, Roger F. Butterworth.

Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.

Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.

Adrianna Michalak, Christopher Rose, Paul N. Buu, Roger F. Butterworth.

OpenAccess
L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

Christopher Rose, Adrianna Michalak, Pierre Pannunzio, Guy Therrien, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, Guy Therrien, Roger F. Butterworth.

OpenAccess
Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

K. Knecht, Adrianna Michalak, Christopher Rose, Jeffrey D. Rothstein, Roger F. Butterworth.

Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.

Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.

Guy Therrien, Christopher Rose, Joanne Butterworth, Roger F. Butterworth.

The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?

The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?

Jean-Pascal de Waele, Robert M. Audet, Christopher Rose, Roger F. Butterworth.

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

Adrianna Michalak, Christopher Rose, Joanne Butterworth, Roger F. Butterworth.

Advances in Hepatic Encephalopathy and Metabolism in Nitrogen Exchange.

Guy Therrien, Christopher Rose, Roger F. Butterworth.