Hepato-neuro lab

Publications

 

Note : Due to licensing rights, we cannot give full access to the pdf files of all our papers (to learn about copyright policies). Those available as open access are indicated by green ribbons. Others articles could be obtain by an institutionnal subscription, if you have access through your institution to these journals. Otherwise, please contact us, we will happily send them to you upon request.

Role of Exercise in the Management of Hepatic Encephalopathy: Experience From Animal and Human Studies.

Luise Aamann, Puneeta Tandon, Chantal Bémeur.

Progressive resistance training prevents loss of muscle mass and strength in bile duct ligated rats.

Luise Aamann, Rafael Ochoa-Sanchez, Mariana Oliveira, Mélanie Tremblay, Chantal Bémeur, Gitte Dam, Hendrik Vilstrup, Niels Kristian Aagaard, Christopher Rose.

Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.

Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.

Rafael Ochoa-Sanchez, Christopher F. Rose.

Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis.

Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis.

Rahima A. Bhanji, Carlos Moctezuma-Velazquez, Andres Duarte-Rojo, Maryam Ebadi, Sunita Ghosh, Christopher Rose, Aldo J. Montano-Loza.

Diagnosis and Management of Hepatic Encephalopathy: A Case-based Guide

Diagnosis and Management of Hepatic Encephalopathy: A Case-based Guide

Julien Bissonnette, Christopher F. Rose.

OpenAccess
Assessment of the spectrum of hepatic encephalopathy: A multicenter study.

Assessment of the spectrum of hepatic encephalopathy: A multicenter study.

Bradley Reuter, Kara Walter, Julien Bissonnette, Michael D. Leise, Jennifer Lai, Puneeta Tandon, Patrick S. Kamath, Scott W. Biggins, Christopher F. Rose, James B. Wade, Jasmohan S. Bajaj.

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

José I. Fortea, Alexander Zipprich, Carolina Fernandez-Mena, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Juan Bañares, Belén Rodríguez-Sánchez, Emilia Cercenado, Marc-André Clément, Christopher F. Rose, Rafael Bañares, Javier Vaquero, Cristina Ripoll.

OpenAccess
The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.

The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study.

U. S. Acute Liver Failure Study Group, Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, U. S. Acute Liver Failure Study Group.

In reply: Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

U. S. Acute Liver Failure Study Group, Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, U. S. Acute Liver Failure Study Group.

The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

Cristina R. Bosoi, Mariana M. Oliveira, Rafael Ochoa-Sanchez, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose, Chantal Bémeur.

Ammonia toxicity: from head to toe?

Ammonia toxicity: from head to toe?

Srinivasan Dasarathy, Rajeshwar P. Mookerjee, Veronika Rackayova, Vinita Rangroo Thrane, Balasubramaniyan Vairappan, Peter Ott, Christopher F. Rose.

Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee, Christopher F. Rose, for US Acute Liver Failure Study Group.

The Nutrition in Cirrhosis Guide.

The Nutrition in Cirrhosis Guide.

Puneeta Tandon, Vanessa DenHeyer, Kathleen P Ismond, Jan Kowalczewski, Maitreyi Raman, Tannaz Eslamparast, Chantal Bémeur, Christopher Rose.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Valentina Agostoni, Soo Hyeon Lee, Vincent Forster, Meriam Kabbaj, Cristina Bosoi, Mélanie Tremblay, Matthias Zadory, Christopher F. Rose, Jean-Christophe Leroux.

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Arthur J. L. Cooper, Chantal Bémeur, Cristina Cudalbu, Gitte Dam, Alexander S. Thrane, Arthur J. L. Cooper, Christopher F. Rose.

Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.

Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy.

Rune Gangsøy Kristiansen, Christopher F. Rose, Lars Marius Ytrebø.

Le bilan hépatique : comment l'interpréter pour une intervention nutritionnelle optimale?

Geneviève Huard, Catherine Vincent, Chantal Bémeur.

Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure.

Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure.

Geir I. Nedredal, Kjetil Elvevold, Marcio F. Chedid, Lars M. Ytrebø, Christopher F. Rose, Sambit Sen, Bård Smedsrød, Rajiv Jalan, Arthur Revhaug.

Studies on Hepatic Disorders

Chantal Bémeur.

Pivotal preclinical trial of the spheroid reservoir bioartificial liver.

Pivotal preclinical trial of the spheroid reservoir bioartificial liver.

Jaime M. Glorioso, Shennen A. Mao, Brian Rodysill, Taufic Mounajjed, Walter K. Kremers, Faysal Elgilani, Raymond D. Hickey, Hakon Haugaa, Christopher F. Rose, Bruce Amiot, Scott L. Nyberg.

Reply to: "Pivotal preclinical trial of the spheroid reservoir bioartificial liver".

Reply to: "Pivotal preclinical trial of the spheroid reservoir bioartificial liver".

Jaime M. Glorioso, Shennen A. Mao, Brian Rodysill, Taufic Mounajjed, Walter K. Kremers, Faysal Elgilani, Raymond D. Hickey, Hakon Haugaa, Christopher F. Rose, Bruce Amiot, Scott L. Nyberg.

Nutritional status of HIV-infected patients during the first year HAART in two West African cohorts.

Maryline Sicotte, Chantal Bémeur, Assane Diouf, Maria Victoria Zunzunegui, Vinh-Kim Nguyen, ATARAO initiative.

OpenAccess
Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients.

Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients.

Yan Burelle, Chantal Bémeur, Marie-Eve Rivard, Julie Thompson Legault, Gabrielle Boucher, L. S. F. C. Consortium, Charles Morin, Lise Coderre, Christine Des Rosiers.

La nutrition et les maladies hépatiques

Chantal Bémeur.

OpenAccess
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Cristina R. Bosoi, Claudia Zwingmann, Helen Marin, Christian Parent-Robitaille, Jimmy Huynh, Mélanie Tremblay, Christopher F. Rose.

Éditorial: Les maladies rares, non moins importantes.

Chantal Bémeur, Marie-Eve Lavoie.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

Modern nutrition in health and disease.

Chantal Bémeur, Roger F. Butterworth.

Nutrition in the management of cirrhosis and its neurological complications.

Chantal Bémeur, Roger F. Butterworth.

L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.

Rune Gangsøy Kristiansen, Christopher F. Rose, Ole-Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø.

The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus.

The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus.

Piero Amodio, Chantal Bémeur, Roger Butterworth, Juan Cordoba, Akinobu Kato, Sara Montagnese, Misael Uribe, Hendrik Vilstrup, Marsha Y. Morgan.

OpenAccess
Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Cristina R. Bosoi, Christopher F. Rose.

Astrocyte glutamine synthetase: pivotal in health and disease.

Astrocyte glutamine synthetase: pivotal in health and disease.

Christopher F. Rose, Alexei Verkhratsky, Vladimir Parpura.

Neurological complications post-liver transplantation: impact of nutritional status.

Neurological complications post-liver transplantation: impact of nutritional status.

Chantal Bémeur.

Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema.

Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema.

Chantal Bémeur, Roger F. Butterworth.

OpenAccess
Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Jimmy Huynh, Christian Parent-Robitaille, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy.

Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy.

Christopher F. Rose.

Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.

Vikram Sharma, Gabriella A. M. Ten Have, Lars Ytrebø, Sambit Sen, Christopher F. Rose, R. Neil Dalton, Charles Turner, Arthur Revhaug, Hans M. H. van Eijk, Nicolaas E. P. Deutz, Rajiv Jalan, Rajeshwar P. Mookerjee, Nathan A. Davies.

OpenAccess
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Keith Anderson, Mélanie Tremblay, Christopher F. Rose.

Neurochemical Mechanisms in Disease. Advances in Neurobiology.

Chantal Bémeur, Jane A. Montgomery, Roger F. Butterworth.

N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms.

N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms.

Chantal Bémeur, Javier Vaquero, Paul Desjardins, Roger F. Butterworth.

Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse.

Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse.

Chantal Bémeur, Paul Desjardins, Roger F. Butterworth.

IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure.

IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure.

Chantal Bémeur, Hong Qu, Paul Desjardins, Roger F. Butterworth.

OpenAccess
Neuropathological changes in the brain of pigs with acute liver failure.

Neuropathological changes in the brain of pigs with acute liver failure.

Rune Gangsøy Kristiansen, Sigurd Lindal, Kate Myreng, Arthur Revhaug, Lars Marius Ytrebø, Christopher F. Rose.

OpenAccess
Increase brain lactate in hepatic encephalopathy: Cause or consequence?

Increase brain lactate in hepatic encephalopathy: Cause or consequence?

Christopher F. Rose.

OpenAccess
Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Xiaoling Yang, Cristina R. Bosoi, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy.

Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy.

Chantal Bémeur, Paul Desjardins, Roger F. Butterworth.

Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure.

Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure.

Chantal Bémeur, Paul Desjardins, Roger F. Butterworth.

OpenAccess
Identifying the direct effects of ammonia on the brain.

Identifying the direct effects of ammonia on the brain.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.

L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.

Lars Marius Ytrebø, Rune Gangsøy Kristiansen, Hanne Maehre, Ole Martin Fuskevåg, Trine Kalstad, Arthur Revhaug, María Jover Cobos, Rajiv Jalan, Christopher F. Rose.

OpenAccess
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.

Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.

Christopher Rose, Lars M. Ytrebø, Nathan A. Davies, Sambit Sen, Geir I. Nedredal, Mireille Bélanger, Arthur Revhaug, Rajiv Jalan.

Increased oxidative stress during hyperglycemic cerebral ischemia.

Chantal Bémeur, Line Ste-Marie, Jane Montgomery.

Comparison of two rat models of cerebral ischemia under hyperglycemic conditions.

Longshan Liu, Ziying Wang, Xiang Wang, Lijun Song, Huifang Chen, Chantal Bémeur, Line Ste-Marie, Jane Montgomery.

OpenAccess
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.

Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.

Nicolas Chatauret, Paul Desjardins, Claudia Zwingmann, Christopher Rose, K. V. Rama Rao, Roger F. Butterworth.

Effect of ammonia on astrocytic glutamate uptake/release mechanisms.

Effect of ammonia on astrocytic glutamate uptake/release mechanisms.

Christopher Rose.

OpenAccess
Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

Sambit Sen, Christopher Rose, Lars M. Ytrebø, Nathan A. Davies, Geir I. Nedredal, Synnøve S. Drevland, Marianne Kjønnø, Frits W. Prinzen, Stephen J. Hodges, Nicolaas E. P. Deutz, Roger Williams, Roger F. Butterworth, Arthur Revhaug, Rajiv Jalan.

OpenAccess
Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.

Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.

Lars M. Ytrebø, Sambit Sen, Christopher Rose, Gabrie A. M. Ten Have, Nathan A. Davies, Stephen Hodges, Geir I. Nedredal, Manuel Romero-Gomez, Roger Williams, Arthur Revhaug, Rajiv Jalan, Nicolaas E. P. Deutz.

OpenAccess
Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.

Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.

Lars M. Ytrebø, Sambit Sen, Christopher Rose, Nathan A. Davies, Geir I. Nedredal, Ole-Martin Fuskevåg, Gabrie A. M. Ten Have, Frits W. Prinzen, Roger Williams, Nicolaas E. P. Deutz, Rajiv Jalan, Arthur Revhaug.

OpenAccess
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.

Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.

Christopher Rose, Vicente Felipo.

OpenAccess
Keeping cool in acute liver failure: rationale for the use of mild hypothermia.

Keeping cool in acute liver failure: rationale for the use of mild hypothermia.

Javier Vaquero, Christopher Rose, Roger F. Butterworth.

OpenAccess
Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

Mireille Bélanger, Paul Desjardins, Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat.

Chantal Bémeur, Line Ste-Marie, Paul Desjardins, Luc Vachon, Roger F. Butterworth, Alan S. Hazell, Jane Montgomery.

Therapeutic Hypothermia.

Therapeutic Hypothermia.

Rajiv Jalan, Christopher Rose.

OpenAccess
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

Christopher Rose, Wolfgang Kresse, Helmut Kettenmann.

Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat.

Chantal Bémeur, Line Ste-Marie, Paul Desjardins, Roger F. Butterworth, Luc Vachon, Jane Montgomery, Alan S. Hazell.

Decreased beta-actin mRNA expression in hyperglycemic focal cerebral ischemia in the rat.

Chantal Bémeur, Line Ste-Marie, Paul Desjardins, Alan S. Hazell, Luc Vachon, Roger Butterworth, Jane Montgomery.

OpenAccess
Hypothermia in acute liver failure.

Hypothermia in acute liver failure.

Rajiv Jalan, Christopher Rose.

Albumin dialysis: a new therapeutic strategy for intoxication from protein-bound drugs.

Sambit Sen, Lars M. Ytrebø, Christopher Rose, Ole-Martin Fuskevåg, Nathan A. Davies, Geir I. Nedredal, Roger Williams, Arthur Revhaug, Rajiv Jalan.

OpenAccess
Contractile response of femoral arteries in pigs with acute liver failure.

Contractile response of femoral arteries in pigs with acute liver failure.

Lars M. Ytrebø, S. Ekse, Sambit Sen, Christopher Rose, Geir I. Nedredal, O.-M. Fuskevåg, Rajiv Jalan, Arthur Revhaug.

OpenAccess
Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia.

Claudia Zwingmann, Nicolas Chatauret, Christopher Rose, Dieter Leibfritz, Roger F. Butterworth.

OpenAccess

Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.

Paul Desjardins, Anny Sauvageau, Alain Bouthillier, Darren Navarro, Alan S. Hazell, Christopher Rose, Roger F. Butterworth.

Encephalopathy and Nitrogen Metabolism in Liver Failure

Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

OpenAccess
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

Nicolas Chatauret, Claudia Zwingmann, Christopher Rose, Dieter Leibfritz, Roger F. Butterworth.

OpenAccess
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

Nicolas Chatauret, Christopher Rose, Roger F. Butterworth.

OpenAccess
Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?

Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release?

Christopher Rose.

OpenAccess

Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis.

Anny Sauvageau, Paul Desjardins, Violina Lozeva, Christopher Rose, Alan S. Hazell, Alain Bouthillier, Roger F. Butterworth.

OpenAccess
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

Nicolas Chatauret, Christopher Rose, Guy Therrien, Roger F. Butterworth.

OpenAccess

Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.

Adrianna Michalak, Christopher Rose, Roger F. Butterworth.

Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia.

Line Ste-Marie, Alan S. Hazell, Chantal Bémeur, Roger Butterworth, Jane Montgomery.

Hydroxyl radical production in the cortex and striatum in a rat model of focal cerebral ischemia.

Line Ste-Marie, Pascal Vachon, Luc Vachon, Chantal Bémeur, Marie-Claude Guertin, Jane Montgomery.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, Roger F. Butterworth, Joseph Zayed, Laurent Spahr, Pierre-Michel Huet, Gilles Pomier-Layrargues.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, K. V. Rama Rao, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure.

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure.

Christopher Rose, Adrianna Michalak, Marc Pannunzio, Nicolas Chatauret, Andrea Rambaldi, Roger F. Butterworth.

OpenAccess
Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.

Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle.

Paul Desjardins, K. V. Rao, Adrianna Michalak, Christopher Rose, Roger F. Butterworth.

OpenAccess
Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction.

Christopher Rose, Roger F. Butterworth, Joseph Zayed, Louise Normandin, Kathryn Todd, Adrianna Michalak, Laurent Spahr, Pierre-Michel Huet, Gilles Pomier-Layrargues.

L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.

L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure.

Christopher Rose, Adrianna Michalak, K. V. Rama Rao, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate.

Line Ste-Marie, Luc Vachon, Chantal Bémeur, Jean Lambert, Jane Montgomery.

OpenAccess
Role of manganese in the pathogenesis of portal-systemic encephalopathy.

Role of manganese in the pathogenesis of portal-systemic encephalopathy.

Gilles P. Layrargues, Christopher Rose, Laurent Spahr, Joseph Zayed, Louise Normandin, Roger F. Butterworth.

Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.

Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.

Adrianna Michalak, Christopher Rose, Paul N. Buu, Roger F. Butterworth.

OpenAccess
L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

Christopher Rose, Adrianna Michalak, Pierre Pannunzio, Guy Therrien, Günter Quack, Gerald Kircheis, Roger F. Butterworth.

The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?

The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?

Jean-Pascal de Waele, Robert M. Audet, Christopher Rose, Roger F. Butterworth.

Advances in Hepatic Encephalopathy and Metabolism in Liver Disease.

Christopher Rose, Guy Therrien, Roger F. Butterworth.

OpenAccess
Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

K. Knecht, Adrianna Michalak, Christopher Rose, Jeffrey D. Rothstein, Roger F. Butterworth.

Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.

Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.

Guy Therrien, Christopher Rose, Joanne Butterworth, Roger F. Butterworth.

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

Adrianna Michalak, Christopher Rose, Joanne Butterworth, Roger F. Butterworth.

Oser avoir faim – manger avec plaisir et maigrir.

Chantal Bémeur, C Caty.

Advances in Hepatic Encephalopathy and Metabolism in Nitrogen Exchange.

Guy Therrien, Christopher Rose, Roger F. Butterworth.