Hepato-neuro lab

Cristina Bosoi, MD, Ph.D.

Cristina Bosoi

 Pathogenesis of cerebral edema in minimal hepatic encephalopathy: role of oxidative stress and lactate.

Ph.D., Biomedical science, Université de Montréal, FRQS

Direction:

 2008 - 2015

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Related Publications

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis.

José I. Fortea, Alexander Zipprich, Carolina Fernandez-Mena, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Juan Bañares, Belén Rodríguez-Sánchez, Emilia Cercenado, Marc-André Clément, Christopher F. Rose, Rafael Bañares, Javier Vaquero, Cristina Ripoll.

Oral

Liposome-supported peritoneal dialysis for the treatment of hyperammonemia-associated encephalopathy.

Valentina Agostoni, G. Giacalone, Cristina R. Bosoi, Christopher F. Rose, Jean-Christophe Leroux.

The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis.

Cristina R. Bosoi, Mariana M. Oliveira, Rafael Ochoa-Sanchez, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose, Chantal Bémeur.

Oral

Oral Ornithine Phenylacetate Attenuates Muscle Mass Loss and Prevents Hepatic Encephalopathy in BDL Rats.

Marc-André *Clément, Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose.

Developing a new animal model of obesity and chronic liver disease for the study of hepatic encephalopathy.

Rafael Ochoa-Sanchez, Mélanie Tremblay, Mariana Oliveira, Cristina Bosoi, Marc-André Clément, Christopher F. Rose.

Oral

Beneficial effects of ornithine phenylacetate to attenuate muscle mass loss and to prevent hepatic encephalopathy in experimental cirrhosis.

Christopher F. *Rose, Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabriella A. Ten Have, Nicolaas E. Deutz, Christopher F. Rose.

Oral

Ornithine phenylacetate attenuates loss of muscle mass and improves hepatic encephalopathy in bile-duct ligated rats.

Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabrie Ten Have, Nicholaas Deutz, Christopher F. Rose.

Estudio del efecto de la enoxaparina sobre la cirrosis e hipertensión portal experimental.

Jose Ignacio Fortea, Alexander Zipprich, Carolina Mena Fernandez, Christopher F. Rose, Juan Bañares, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Marc-André Clément, Javier Vaquero, Rafael Bañares, Cristina Ripoll.

Oral

Minimal hepatic encephalopathy renders the brain susceptible to hypotension-induced neuronal cell loss in BDL rats.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Leucine et exercices : bénéfique lors d'encéphalopathie expérimentale.

Corine Fontaine, Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Liposome-supported peritoneal dialysis for the treatment of hepatic encephalopathy.

Valentina Agostoni, Soo Hyeon Lee, Vincent Forster, Meriam Kabbaj, Cristina Bosoi, Mélanie Tremblay, Matthias Zadory, Christopher F. Rose, Jean-Christophe Leroux.

Long term oral treatment of ornithine phenylacetate increases lean mass and attenuates brain edema in bile-duct ligated rats.

Cristina R. Bosoi, Mariana Oliveira, Marc-André Clément, Mélanie Tremblay, Gabrie Ten Have, Nicolaas E. P. Deutz, Christopher F. Rose.

Oral

Minimal hepatic encephalopathy leads to hypotension-induced neuronal cell loss in BDL rats.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Enoxaparin treatment does not ameliorate liver fibrosis or portal hypertension in experimental models of cirrhosis in rats.

Jose Ignacio Fortea, Alexander Zipprich, Carolina-Mena Fernandez, Christopher F. Rose, Juan Bañares, Marta Puerto, Cristina R. Bosoi, Jorge Almagro, Marcus Hollenbach, Marc-André Clément, Javier Vaquero, Rafael Bañares, Cristina Ripoll.

Liposome-Supported Peritoneal Dialysis in the Treatment of Severe Hyperammonemia.

Valentina Agostoni, Vincent Forster, Cristina Bosoi, Mélanie Tremblay, Christopher Rose, Jean-Christophe Leroux.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Bile-ligated rats are susceptible to hypotension-induced neuronal cell loss: implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Muscle mass optimization prevents experimental hepatic encephalopathy.

Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Diminution du compte neuronal par une insulte hypotensive chez le rat avec ligation de la voie biliaire: implications pour la persistance des complications neurologiques après transplantation hépatique.

Marc-André Clément, Cristina R. Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

Optimizing muscle mass: therapeutic target to prevent experimental hepatic encephalopathy.

Chantal *Bémeur, Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased BBB permeability via NKCC1.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Beneficial effects of muscle mass optimization using leucine supplementation and exercise training in the prevention of hepatic encephalopathy in experimental cirrhosis.

Chantal *Bémeur, Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Bumetanide normalizes brain edema in rats with bile duct ligation: evidence for increased bbb permeability via NKCC1.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Bile-duct ligated rats are susceptible to hypotension-induced neuronal cell loss: Implications for persisting neurological complications following liver transplantation.

Marc-André Clément, Cristina Bosoi, Mélanie Tremblay, Chantal Bémeur, Christopher F. Rose.

Oral

The novel glutaminase inhibitor CB-839 prevents oral glutamine-induced hyperammonemia in portacaval shunted rats.

Cristina R. Bosoi, Marc-André Clément, Mélanie Tremblay, Christopher F. Rose.

Systemic oxidative stress induction leads to brain edema in hyperammonemic portacaval-shunted rats.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Glutathione depletion leads to brain edema in portacaval-shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Beneficial effects of muscle mass optimization using leucine supplementation and exercise training in the prevention of hepatic encephalopathy in experimental cirrhosis.

Sara Ghezzal, Marc-André Clément, Cristina R. Bosoi, Roxanne Beauchamp, Mélanie Tremblay, Christopher F. Rose, Chantal Bémeur.

Impact of muscle mass optimization in the prevention of hepatic encephalopathy in experimental cirrhosis.

Chantal Bémeur, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Inhibiting lactate synthesis: a new therapeutic target for the treatment of hepatic encephalopathy.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.

Cristina R. Bosoi, Claudia Zwingmann, Helen Marin, Christian Parent-Robitaille, Jimmy Huynh, Mélanie Tremblay, Christopher F. Rose.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

Oral

L'impact de l’isoleucine et de l’exercice physique sur l’état métabolique, la masse musculaire et l’encéphalopathie hépatique chez des rats cirrhotiques.

Cristina R. *Bosoi, Chantal Bémeur, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Impact of isoleucine and exercise on metabolic state, muscle mass and hepatic encephalopathy in cirrhotic rats.

Chantal Bémeur, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Attenuation of oxidative stress protects the brain in rats with “acute-on-chronic” liver failure.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Systemic oxidative stress induction aggravates hepatic encephalopathy in hyperammonemic portacaval-shunted rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Chronic hyperammonemia “priming” alleviates the induction of oxidative stress and development of brain edema following an acute liver insult.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Oral

Le méthylglyoxal et l'encéphalopathie hépatique.

Vi T. Tran, Laurent Bilodeau, Cristina R. Bosoi, Mélanie Tremblay, Mireille Bélanger, Christopher F. Rose.

OpenAccess
Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy.

Cristina R. Bosoi, Christopher F. Rose.

OpenAccess
Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Brain edema in acute liver failure and chronic liver disease: Similarities and differences.

Cristina R. Bosoi, Christopher F. Rose.

L'encéphalopathie hépatique sévère est retardée chez des rats souffrant d’une décompensation hépatique aigue durant une hyperammoniémie chronique.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Le méthylglyoxal et l'encéphalopathie hépatique.

Vi T. Tran, Laurent Bilodeau, Cristina R. Bosoi, Mélanie Tremblay, Mireille Bélanger, Christopher F. Rose.

Onset of severe hepatic encephalopathy is delayed in rats with acute liver insult superimposed on chronic hyperammonemia compared to rats with acute liver failure: a look at underlying mechanisms.

Cristina R. Bosoi, Chantal Bémeur, Bich Nguyen, Mélanie Tremblay, Christopher F. Rose.

Role of cerebral lactate in the pathogenesis of brain edema in cirrhotic rats.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Le rôle de l'encéphalopathie hépatique dans la susceptibilité accrue à l’insulte neuronale induite par hypotension/ hypoxie cérébrale.

Christian Parent-Robitaille, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Increased cerebral lactate contributes to brain edema in cirrhotic rats.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Implication de la glutaminase dans l'insuffisance hépatique chronique.

Ada Rivera, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Role of oxidative stress in prevention of brain edema during an acute deterioration of chronic liver failure.

Cristina R. *Bosoi, Chantal Bémeur, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

Le rôle du stress oxydatif dans la pathogenèse de l’œdème cérébral dans l’encéphalopathie hépatique.

Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

L'inhibition de la xanthine oxydase atténue l'oedème cérébral chez des rats avec insuffisance hépatique chronique.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Systemic oxidative stress induction leads to brain edema in hyperammonemic portacaval-shunted rats.

Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Glutathione depletion leads to brain edema in portacaval-shunted rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Xanthine oxidase inhibition attenuates brain edema in in rats with liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Jimmy Huynh, Christian Parent-Robitaille, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

Allopurinol attenuates systemic oxidative stress and hyperammonemia in bile-duct ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Evidence systemic oxidative stress represents a “first hit” in the multifactorial pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Impaired lactate metabolism, not brain ammonia and glutamine, contributes to the pathogenesis of brain edema in minimal hepatic encephalopathy.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Systemic oxidative stress followed by increases in ammonia and lactate is involved in the pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Oral

Na-K-Cl cotransporter is implicated in the pathogenesis of brain edema in rats with bile duct ligation.

Jimmy Huynh, Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Keith Anderson, Mélanie Tremblay, Christopher F. Rose.

Le cotransporteur Na-K-Cl est impliqué dans la pathogénèse de l’œdème cérébral chez les rats avec une ligature de la voie biliaire.

Jimmy Huynh, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

L'augmentation de novo du lactate cérébral, indépendamment des niveaux d’ammoniaque et glutamine, est impliquée dans la pathogénèse de l’œdème cérébral dans l’insuffisance hépatique chronique.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Increased de novo synthesis of brain lactate, independent of brain ammonia and glutamine, is implicated in the pathogenesis of brain edema in chronic liver failure.

Cristina R. Bosoi, Claudia Zwingmann, Jimmy Huynh, Helen Marin, Mélanie Tremblay, Christopher F. Rose.

Dose dependent effects of AST-120 (spherical carbon adsorbent) on arterial ammonia, brain edema, and systemic inflammatory marker (TNF-a) in bile duct ligated rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

AST-120 (spherical carbon adsorbent) treatment prevents hyperammonemia and brain edema in cirrhotic rats.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.

Xiaoling Yang, Cristina R. Bosoi, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose.

Oral

AST-120 (adsorbant sphérique de charbon) atténue l'œdème cérébral et diminue le niveau artériel d'ammoniaque chez les rats avec ligature de voie biliaire.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

L'œdème cérébral est associé avec le stress oxydatif systémique et non central dans les rats avec ligature de la voie biliaire.

Xiaoling Yang, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose.

Oral

AST-120 (spherical carbon adsorbent) attenuates brain edema and lowers arterial ammonia in bile duct ligated rats.

Christopher F. *Rose, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation.

Xiaoling Yang, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

AST-120 (spherical carbon adsorbent) lowers arterial ammonia and attenuates brain edema in bile-duct ligated rats.

Christopher F. *Rose, Cristina Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation.

Xiaoling Yang, Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

L'effet synergique du stress oxydatif et l'hyperammonémie mène à l'œdème cérébral chez des rats avec une insuffisance hépatique chronique.

Cristina R. Bosoi, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Oral

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Xiaoling Yang, Wenlei Jiang, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

OpenAccess
Identifying the direct effects of ammonia on the brain.

Identifying the direct effects of ammonia on the brain.

Cristina R. Bosoi, Christopher F. Rose.

Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure.

Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose.

Hyperammonemia does not induce oxidative/nitrosative stress in rats with portacaval anastomosis.

Cristina Bosoi, Mélanie Tremblay, Christopher F. Rose.